IL-10在多房棘球蚴病免疫抑制微环境中的作用研究进展

doi:10.12140/j.issn.1000-7423.2025.05.016

中国寄生虫学与寄生虫病杂志 ›› 2025, Vol. 43 ›› Issue (5): 705-710.doi: 10.12140/j.issn.1000-7423.2025.05.016

IL-10在多房棘球蚴病免疫抑制微环境中的作用研究进展

王淑君¹^,²(), 韩菲², 张慧霞², 种世桂¹, 赵玉敏¹^,²^,^*()

1 甘肃医学院基础医学院，甘肃平凉 744000
2 桂林医科大学公共卫生学院，广西桂林 541000

收稿日期:2025-04-30 修回日期:2025-07-17 出版日期:2025-10-30 发布日期:2025-10-13
通讯作者: *赵玉敏，男，博士，教授，从事寄生虫病防治研究。E-mail：zymcsg@sina.com
作者简介:王淑君，女，硕士研究生，从事寄生虫病防治研究。E-mail：shujunwang1998@163.com
基金资助:
甘肃省高等学校产业支撑计划(2022CYZC-72);平凉市崆峒区科技计划项目-重点研发项目(PL-KT-204-2-006);甘肃省重点人才项目

Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis

WANG Shujun¹^,²(), HAN Fei², ZHANG Huixia², ZHONG Shigui¹, ZHAO Yumin¹^,²^,^*()

1 School of Basic Medical Sciences, Gansu Medical College, Pingliang 744000, Gansu, China
2 School of Public Health, Guilin Medical University, Guilin 541000, Guangxi, China

Received:2025-04-30 Revised:2025-07-17 Online:2025-10-30 Published:2025-10-13
Contact: *E-mail: zymcsg@sina.com
Supported by:
Gansu Provincial Higher Education Industry Support Program(2022CYZC-72);Kongtong District Key Research and Development Project of Science and Technology Program in Pingliang City(PL-KT-204-2-006);Gansu Provincial Key Talent Program

摘要/Abstract

摘要：

多房棘球蚴病是由多房棘球绦虫的幼虫（多房棘球蚴）寄生在宿主体内所引起的一种人兽共患寄生虫病。多房棘球蚴作为外源性物质持续感染宿主，导致宿主细胞免疫功能抑制和细胞因子分泌紊乱，在体内形成一种特殊的微环境。其中白细胞介素-10（IL-10）作为一种抗炎性细胞因子，在棘球蚴病免疫调控中发挥着重要作用。本文介绍了多房棘球蚴病免疫抑制微环境的形成，分析了IL-10的生物学特性、对免疫细胞功能的影响以及细胞因子的相互作用，探讨其在多房棘球蚴病免疫抑制微环境中的作用机制，为多房棘球蚴病的治疗提供新的理论依据和潜在治疗靶点。

关键词: 多房棘球蚴病, 免疫抑制, 免疫微环境, 白细胞介素-10

Abstract:

Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by infection with Echinococcus multilocularis larvae in hosts. As an exogenous substance, persistent larval E. multilocularis infections lead to suppression of cellular immune functions and dysregulation of cytokine secretion in hosts, thereby creating a unique immunosuppressive microenvironment in hosts. As a key anti-inflammatory cytokine, interleukin-10 (IL-10) plays a pivotal role in the immunomodulation of echinococcosis. This review presents the formation of the immunosuppressive microenvironment of AE, analyzes the biological characteristics of IL-10, its regulatory effects on immune cell functions, and its interplay with other cytokines, and discusses the mechanisms of the contribution of IL-10 to shaping the immunosuppressive microenvironment of AE, so as to provide new theoretical evidence for AE treatment and potential therapeutic targets of AE.

Key words: Alveolar echinococcosis, Immunosuppression, Immune microenvironment, Interleukin 10

中图分类号:

R532.32

王淑君, 韩菲, 张慧霞, 种世桂, 赵玉敏. IL-10在多房棘球蚴病免疫抑制微环境中的作用研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2025, 43(5): 705-710.

WANG Shujun, HAN Fei, ZHANG Huixia, ZHONG Shigui, ZHAO Yumin. Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2025, 43(5): 705-710.

图/表 1

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IL-10在多房棘球蚴病免疫抑制微环境中的作用研究进展

Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis

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