血吸虫病候选疫苗临床研究进展

doi:10.12140/j.issn.1000-7423.2022.04.015

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (4): 511-515.doi: 10.12140/j.issn.1000-7423.2022.04.015

血吸虫病候选疫苗临床研究进展

陈兵¹(), 张国莉², 张高红¹^,^*()

1.昆明学院医学院,昆明 650214
2.昆明医科大学药学院,昆明 650500

收稿日期:2021-12-27 修回日期:2022-01-20 出版日期:2022-08-30 发布日期:2022-09-07
通讯作者: 张高红
作者简介:陈兵（1982-）,男,博士,从事寄生适应性进化与寄生虫病防治研究。E-mail： chenbing0318@126.com
基金资助:
云南省教育厅科学研究基金项目(2021J0711);国家自然科学基金面上项目(81860486)

Research progress on clinical trials of schistosomiasis vaccine candidates

CHEN Bing¹(), ZHANG Guo-li², ZHANG Gao-hong¹^,^*()

1. School of Medicine, Kunming University, Kunming 650214, China
2. School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China

Received:2021-12-27 Revised:2022-01-20 Online:2022-08-30 Published:2022-09-07
Contact: ZHANG Gao-hong
Supported by:
Scientific Research Fund Project of Yunnan Education Department(2021J0711);National Natural Science Foundation of China(81860486)

摘要/Abstract

摘要：

血吸虫病是由血吸虫寄生而引起的人兽共患寄生虫病,严重危害人类健康,影响社会经济发展。血吸虫病疫苗一直备受关注,有助于降低对吡喹酮的过度依赖,推进控制和消除血吸虫病目标的实现。目前虽然尚无商业化的血吸虫病疫苗,但谷胱甘肽S-转移酶、脂肪酸结合蛋白、四跨膜蛋白-2和钙蛋白酶大亚基等4种候选疫苗已进入不同阶段的人体临床试验。本文对4种血吸虫病候选疫苗的临床研究进展、面临的挑战进行综述,以期为我国血吸虫病疫苗与其他蠕虫病疫苗的研发提供线索和借鉴。

关键词: 血吸虫病, 疫苗, 抗原, 人体临床试验

Abstract:

Schistosomiasis is a wide-spread parasitic zoonosis caused by Schistosoma, which seriously harms human health and affects socioeconomic development worldwide. Schistosomiasis vaccines have attracted much attention as they will contribute not only to reducing the over-reliance on praziquantel for the treatment of this disease but also to achieving the goal of disease control and elimination. There have been no schistosomiasis vaccines available until now; however, four schistosomiasis vaccine candidates, glutathione S-transferase, fatty acid binding protein, tetraspanin-2 and calpain, have entered human clinical trials. This paper reviewed the clinical research progress and challenges of the four schistosomiasis vaccine candidates to provide insights into developing vaccines for schistosomiasis and other helminthiases in China.

Key words: Schistosomiasis, Vaccine, Antigen, Human clinical trial

中图分类号:

R532.21

陈兵, 张国莉, 张高红. 血吸虫病候选疫苗临床研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(4): 511-515.

CHEN Bing, ZHANG Guo-li, ZHANG Gao-hong. Research progress on clinical trials of schistosomiasis vaccine candidates[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(4): 511-515.

图/表 1

参考文献 29

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候选疫苗	抗原	虫种	临床试验阶段	临床（前）试验结果
rSh28GST/Alhydrogel	GST	埃及血吸虫	Ⅰ、Ⅱ、Ⅲ期完成	赤猴组织中虫卵减少50%,随尿液排除虫卵减少80%。Ⅲ期试验中,保护效果未达到预期水平。成人及儿童耐受性良好
Sm14/GLA-SE	FABP	曼氏血吸虫	Ⅰa、Ⅰb、Ⅱa、Ⅱb期完成	完成3次接种后,92%的受试者产生特异性抗体并可持续1年,同时诱导Th1和Th2型免疫应答。成人耐受性良好
Sm-TSP-2/Alhydrogel	TSP-2	曼氏血吸虫	Ⅰa、Ⅰb期完成,Ⅱ期开始	IgG抗体水平显著增长并与疫苗剂量、佐剂选择相关。成人耐受性良好
Sm-p80/GLA-SE	Calpain	曼氏血吸虫	Ⅰ期开始	狒狒免疫后,雌虫减虫率为93%,减卵率为90%,剩余虫卵孵化率降低80%。无IgE抗体应答

血吸虫病候选疫苗临床研究进展

Research progress on clinical trials of schistosomiasis vaccine candidates

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