中国寄生虫学与寄生虫病杂志

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蚊虫先天免疫分子机制的研究进展

郭秀霞, 王怀位*   

  1. 山东省医学科学院,山东省寄生虫病防治研究所,山东省医药卫生媒介生物学重点实验室,济宁 272033
  • 出版日期:2015-02-28 发布日期:2015-05-04
  • 基金资助:

    山东省医学科学院项目(No. 2013?鄄39);国家自然科学基金(No. 81271877,81201318)

Research Progress on the Molecular Mechanisms of Mosquito Innate Immunity

GUO Xiu-xia,WANG Huai-wei *   

  1. Shandong Institute of Parasitic Diseases;Shandong Academy of Medical Sciences;Key Laboratory of Medicine and Health in Shandong Province,Jining 272033,China
  • Online:2015-02-28 Published:2015-05-04
  • Supported by:

    Supported by a project of Shandong Academy of Medical Sciences(No. 2013-39)and the National Natural Science Foundation of China(No. 81271877, 81201318)

摘要:

蚊虫作为蚊媒疾病的重要传播媒介,其抵御病原体的感染主要依赖其自身的先天免疫系统。与其他昆虫类似,蚊虫的先天免疫反应包括细胞免疫和体液免疫,二者相互联系、相互协作,通过模式识别受体识别、免疫信号传导、抗菌肽产生、黑化反应和细胞吞噬等免疫反应抵御病原体的侵染。本文就蚊虫先天免疫分子机制做一综述。

关键词: 蚊, 天然免疫, 分子机制

Abstract:

As the important vector of the mosquito-borne diseases, mosquitos rely on their innate immune system against pathogens infection, which includes cellular immunity and humoral immunity. Both of them are interacted and coordinated, via the pattern recognition receptors, immune signaling, antimicrobial peptides, phenoloxidase-based melanization, phagocytosis, and so on. This paper reviews the research progress on the molecular mechanisms of mosquito innate immunity.

Key words: Mosquito, Innate immunity, Molecular mechanism