中国寄生虫学与寄生虫病杂志 ›› 2013, Vol. 31 ›› Issue (2): 15-151-154.

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旋毛虫对宿主免疫应答调节机制的研究进展

赵葛,杨文涛,王春凤,杨桂连*   

  1. 吉林农业大学动物科学技术学院,吉林省动物微生态制剂工程研究中心,长春130118
  • 出版日期:2013-04-30 发布日期:2013-07-02

Research Progress on the Mechanism of Host Immune Response Regulated by Trichinella spiralis

ZHAO Ge, YANG Wen-tao, WANG Chun-feng, YANG Gui-lian*   

  1. College of Animal Science and Technology, Jinlin Agricultural University, Jilin Provincial Engineering Research Center of Animal Probiotics, Changchun 130118, China
  • Online:2013-04-30 Published:2013-07-02

摘要: 旋毛虫病是由旋毛虫(Trichinella spiralis)引起的一种呈世界性分布的人兽共患寄生虫病,严重影响畜牧业发展和食品安全,从而威胁人类健康。旋毛虫具有逃避宿主免疫应答进而在宿主体内形成长期感染的能力。研究认为,旋毛虫改变宿主免疫状态是其逃避免疫应答的重要原因,其中细胞因子、树突状细胞和调节性T细胞在其调节宿主免疫过程中发挥着重要作用。

关键词: 旋毛虫, Th1/Th2平衡, 细胞因子, 树突状细胞, 调节性T细胞

Abstract: Trichinosis caused by Trichinella spiralis is a parasitic zoonosis with world-wide distribution, which impacts on the development of animal husbandry and food safety, and thus threatens human health. T. spiralis has the ability to evade the host immune response, which results in forming a long-term infection in the host. The previous studies indicated that a changed host immune state due to T. spiralis was an important reason for the evasion. Among the factors, cytokines, dendritic cells and regulatory T cells played an important role in the regulation of the host immune process.

Key words: Trichinella spiralis, Th1/Th2 balance, Cytokine, Dendritic cell, Regulatory T cell