免疫细胞对血吸虫病肝纤维化作用的研究进展

doi:10.12140/j.issn.1000-7423.2022.01.013

中国寄生虫学与寄生虫病杂志 ›› 2022, Vol. 40 ›› Issue (1): 88-93.doi: 10.12140/j.issn.1000-7423.2022.01.013

免疫细胞对血吸虫病肝纤维化作用的研究进展

高元(), 胡媛^*(), 曹建平

中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心）,国家卫生健康委员会寄生虫病原与媒介生物学重点实验室,世界卫生组织热带病合作中心,国家级热带病国际联合研究中心,上海 200025

收稿日期:2021-05-18 修回日期:2021-07-02 出版日期:2022-02-28 发布日期:2022-01-06
通讯作者: 胡媛
作者简介:高元（1996-）,女,硕士研究生,从事寄生虫感染免疫机制研究。E-mail： gyuan1028@126.com
基金资助:
上海市自然科学基金(19ZR1462600);国家科技重大专项(2018ZX10102001);国家自然科学基金面上项目(81971969);国家自然科学基金面上项目(81772225)

Research progress on the role of immune cells in liver fibrosis due to schistosomiasis

GAO Yuan(), HU Yuan^*(), CAO Jian-ping

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China

Received:2021-05-18 Revised:2021-07-02 Online:2022-02-28 Published:2022-01-06
Contact: HU Yuan
Supported by:
Natural Science Foundation of Shanghai(19ZR1462600);National Science and Technology Major Project of the Ministry of Science and Technology of China(2018ZX10102001);National Natural Science Foundation of China(81971969);National Natural Science Foundation of China(81772225)

摘要/Abstract

摘要：

血吸虫病是一种广泛流行的人兽共患寄生虫病。日本血吸虫感染后,虫卵可沉积于宿主的肝脏,形成肉芽肿进而引起肝纤维化,严重者可发展成肝硬化。近年来研究发现,免疫细胞在血吸虫病肝纤维化过程中扮演重要角色。如T辅助性17细胞、γδ T细胞和树突状细胞等促进血吸虫病肝纤维化,调节性T细胞、自然杀伤细胞等抑制肝纤维化,而B细胞、巨噬细胞及自然杀伤T细胞可能发挥双重调节作用。本文就不同免疫细胞在血吸虫病肝纤维化中的作用机制进行综述。

关键词: 血吸虫病, 肝纤维化, 免疫细胞, 细胞因子

Abstract:

Schistosomiasis is a widespread zoonotic parasitic disease. After infected, Schistosoma japonicum deposit eggs in the host liver, forming granulomatous, and consequently leading to liver fibrosis, and even cirrhosis in severe cases. Recent studies have reported that immune cells play critical roles in liver fibrosis. Helper T 17 cells, γδ T cells and dendritic cells may advance schistosomiasis liver fibrosis, while regulatory T cells and natural killer cells suppress the liver fibrosis, and B cells, macrophages and natural killer T cells may play dual roles. Here we reviewed the action mechanisms of different types of immune cells in liver fibrosis of schistosomiasis.

Key words: Schistosomiasis, Liver fibrosis, Immune cell, Cytokine

中图分类号:

R532.21

高元, 胡媛, 曹建平. 免疫细胞对血吸虫病肝纤维化作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(1): 88-93.

GAO Yuan, HU Yuan, CAO Jian-ping. Research progress on the role of immune cells in liver fibrosis due to schistosomiasis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(1): 88-93.

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免疫细胞对血吸虫病肝纤维化作用的研究进展

Research progress on the role of immune cells in liver fibrosis due to schistosomiasis

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