中国寄生虫学与寄生虫病杂志 ›› 2010, Vol. 28 ›› Issue (3): 17-238.

• 研究简报 • 上一篇    下一篇

艾滋病并发弓形虫脑炎16例分析

赵建荣1,张莎1,杜建平2,王舒1,王大勇1   

  1. 1 云南省传染病专科医院综合科,昆明 650301;2 大姚县人民医院急诊科,大姚 675400
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-30 发布日期:2010-06-30

Clinical Analysis of 16 AIDS Patients Complicated withToxoplasmic Encephalitis

ZHAO Jian-rong1,ZHANG Sha1,DU Jian-ping2,WANG Shu1,WANG Da-yong1   

  1. 1 General Department, Infectious Disease Hospital For Yunnan Province,Kunming 650301,China;2 Department of Emergency,The People′s Hospital of Dayao County,Dayao 675400,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-06-30 Published:2010-06-30

摘要: 【提要】 回顾性分析云南省传染病专科医院2008年8月~2009年8月收治的艾滋病合并弓形虫脑炎患者16例,平均年龄(37.0±11.6)岁。临床表现以头痛(68.8%, 11/16)和发热(62.5%, 10/16)等症状多见, 巴氏征阳性占37.5%(6/16), 81.3%(13/16)患者CD4+细胞计数<200/mm3,血液和脑脊液弓形虫抗体TOXO?鄄IgG阳性率均为62.5%(10/16),弓形虫脑炎CT和磁共振(MRI)检查呈双边、多发病灶伴周围水肿,增强扫描示病灶形状以指环状为主。16例患者给予磺胺嘧啶或磺胺嘧啶+克林霉素治疗,其中10例联合高效抗逆转录病毒疗法,15例病情缓解,1例因感染性休克死亡。

关键词: 艾滋病, 弓形虫脑炎, 机会性感染, 临床分析, 治疗

Abstract: 【Abstract】 Sixteen AIDS patients complicated with toxoplasmic encephalitis (TE) were retrospectively analyzed between August 2008 to August 2009 with a mean age of (37.0±11.6) years. The most common clinical symptoms were headache (68.8%, 11/16) and fever (62.5%, 10/16), and 6 with Babinski sign (37.5%). 81.3%(13/16)were with CD4+ cells<200/mm3. Both sera and CSF showed 62.5% (10/16) TOXO-IgG positive by ELISA. CT and MRI scan demonstrated bilateral and multiple lesions with marked peripheral edema effect, and an enhanced scanning showed small finger ring as the major feature. 15 patients got improved by either oral sulphadiazine tablets or sulphadiazine tablets plus clindamycin capsule, 10 cases received combined HAART treatment, and 1 case died with septic shock.

Key words: AIDS, Toxoplasmic encephalitis, Opportunistic infection, Clinical analysis, Therapy