Abstract: Objective To study the expression of interferonγ(IFNγ) and typeⅠinterferon γ receptor (IFN γR1) in the chronic and advanced patients of schistosomiasis japonica, and to discuss its clinical relationship with hepatic fibrosis. Methods IFN γR1 in the peripheral blood lymphocytes was detected by ELISA, and the hyaluronic acid (HA), collagen type Ⅳ(C Ⅳ), procollagen type Ⅲ (PCⅢ), laminin (LN) were detected by radio immunoassay (RIA) in schistosomiasis patients. The level of IFN γ, IFN γR1 and serum markers of hepatic fibrosis were observed, and the relationship with each other was analyzed by statistical method. Results There was no difference in the expression of IFN γ and IFN γR1 between the patients with chronic schistosomiasis and the normal group ( P>0.05), the IFN γR1 in advanced cases without splenectomy was low ( P <0.05), but IFN γ was high( P<0.01). The two indicators in the advanced schistosomiasis patients with splenectomy returned to normal. There was no corresponding relationship between the two indicators and HA, C Ⅳ,PCⅢ,LN with a r value of 0.19, 0.20, 0.14, and 0.21 respectively. Conclusion There is a corresponding relationship between IFN γ and IFN γR1; the expression of IFN γR1 is related to the course of schistosomiasis, and the relationship with hepatic fibrosis needs further study.

Key words: Schistosomiasis, Interferon-γ receptor, Interferon-γ, Liver fibrosis