EFFECT OF TRICLABENDAZOLE ON EXPERIMENTAL PARAGONIMIASISWESTERMANI IN DOGS

›› 1997, Vol. 15 ›› Issue (5): 263-265.

• 论著 • Previous Articles     Next Articles

EFFECT OF TRICLABENDAZOLE ON EXPERIMENTAL PARAGONIMIASISWESTERMANI IN DOGS

Gao Jingsong; L iu Yuehan; Wang Xiaogen; Yu Denggao; Shu Qun   

  1. Institute of Infectious and Parasitic Diseases Chongqing University of Medical Sciences; Chongqing 400016
  • Received:1900-01-01 Revised:1900-01-01 Online:1997-10-30 Published:1997-10-30

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Abstract: AIM:To observe the therapeutic effect of triclabendazole in the treatment of dogs
with paragonimiasis westermani.METHODS:Six dogs were experimentally infected each with 1 0 0
metacercariae of Paragonimus westermani intraperitoneally and divided into untreated and treated
groups,3dogs were treated orally with triclabendazole 1 0 0 mg/kg· d for 2 con- secutive days
at d 1 70 post infection.Stool egg count was done with Stoll method.All of these dogs were
killed at38days after treatmentand the number of worm eysts and worms in the lungs were examined by naked eye and microscopically. RESULTS: Stool eggs became negative from d7 to d14 after starting chemotherapy in treated dogs, the number of worm cysts in the lungs of untreated dogs were 18, 24 and 24 on necropsy, while those in the treated dogs were 10, 7 and 4, respectively. The number of adult worms in the untreated dogs were 38, 51 and 42, while in the treated dogs only 2 smaller adult worms were found in one dog and no worm was found in the other two dogs. The mean worm reduction rate was 98.5%. CONCLUSION: Triclabendazole is highly active against Paragonimus westermani in experimenal infected dogs

Key words: Paragonimus westerm ani, triclabendazole, metacercariae, praziquantel