THE PROTECTIVE EFFECT AGAINST TOXOPLASMA INFECTION IN MICE IMMUNIZED WITH LASER-IRRADIATED TOXOPLASMA TACHYZOITES*

›› 1999, Vol. 17 ›› Issue (6): 19-389.

• 实验研究 • Previous Articles Next Articles

THE PROTECTIVE EFFECT AGAINST TOXOPLASMA INFECTION IN MICE IMMUNIZED WITH LASER-IRRADIATED TOXOPLASMA TACHYZOITES*

LIN Aifen¹;LU Shaohong¹;CHEN Caihua¹;LI Siwen¹;CHEN Rui¹;LU Xuanhui²;HUANG Fuquan²

1 Institute of Parasitic Diseases;Zhejiang Academy of Medical Sciences;Hangzhou 310013 2 Physics Department;Hangzhou University;Hangzhou 310028

Received:1900-01-01 Revised:1900-01-01 Online:1999-12-30 Published:1999-12-30

Abstract

Abstract: 　AIM: To observe the level of immune responses and protective immunity in mice induced by laser-irradiated Toxoplasma tachyzoites (LIT).METHODS: ICR mice were immunized with LIT. After one month, the mice were challenged with live Toxoplasma tachyzoites to observe the effect of LIT. Indirect immunofluorescence assay and ELISA were used to detect CD4+/CD8+ lymphocyte subpopulation and IgG antibody. RESULTS: Immunization with LIT could partially protect the mice from Toxoplasma infection, prolong the survival time, enhance the CD4+/CD8+ ratio and produce specific IgG antibody. CONCLUSION: Intraperitoneal injection with LIT can induce partial protective immunity and specifically elicit ICR mice to generate humoral and cell-mediated immune responses.\;

Key words: Laser-irradiation, Toxoplasma tachyzoite, immune response

LINAifen;LUShaohong;CHENCaihua;LISiwen;CHENRui;LUXuanhui;HUANGFuquan. THE PROTECTIVE EFFECT AGAINST TOXOPLASMA INFECTION IN MICE IMMUNIZED WITH LASER-IRRADIATED TOXOPLASMA TACHYZOITES*[J]. , 1999, 17(6): 19-389.

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THE PROTECTIVE EFFECT AGAINST TOXOPLASMA INFECTION IN MICE IMMUNIZED WITH LASER-IRRADIATED TOXOPLASMA TACHYZOITES*

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