Abstract: 　Objective] To compare the pharmacokinetic differences of chloroquine in normal mice and the mice infected with the N and the RC strains of Plasmodium berghei . [Methods] The concentrations of chloroquine in the plasma of normal mice and the mice infected with the N or the RC strains of P. berghei were analyzed by reverse phase HPLC. The pharmacokinetic parameters were measured with software 3P87. [Results] The t 1/2 β value was significantly lower in the mice infected with the RC strain than in normal mice and the mice infected with the N strain( P <0.05), however, there were no significant differences between the mice infected with the N strain and normal mice. [Conclusion] Elimination of chloroquine in the mice infected with the RC strain of P. berghei speed up significantly comparing with the mice infected with the N strain.

Key words: Plasmodium berghei, chloroquine, pharmacokinetics, HPLC