Abstract: 　Objective] To investigate the presence of anti- Toxoplasma gondii antibodies in immunodeficient patients. [Methods] T gondii -specific immunoglobulin G (IgG) antibodies in serum samples from 371 immunodeficient patients were detected by enzyme-linked immunosorbent assay (ELISA). The patients were with solid malignancies (including untreated digestive system malignancies and solid malignancies received chemotherapy), chronic liver diseases, patients received immunosuppressant therapy (dermatomyositis, psoriasis, pemphigus, post-renal transplantation, systemic lupus erythematosus and other miscellanies), lymphoma, leukemia and diabetes. 100 normal serum samples served as controls. [Results] The positive rate of patients with solid malignancies received chemotherapy, solid malignancies received chemotherapy, chronic liver diseases, systemic lupus erythematosus and leukemia was 19 0%, 33 3%, 16 5%, 45 4% and 20 0%, respectively,being significantly higher than that of the control group( P <0 05). [Conclusion] The immunosuppressed patients are highly predisposing to secondary T.gondii infection .

Key words: immunodeficient, toxoplasmosis, enzyme-linked immunosorbent assay (ELISA)