Progress towards mosquito microbiome on regulating the transmission of mosquito-borne diseases

doi:10.12140/j.issn.1000-7423.2019.05.017

Abstract

Abstract:

Mosquito is a hematophagous insect which transmits malaria, dengue fever or Zika infections by blood feeding, posing fatal threats to global public health. Mosquito midgut is the first line of defense against infected pathogens. When mosquito feeds on a host with virus or parasite infections, the pathogens in the host blood are ingested into the midgut in which variant commensal microbes harbor. Some commensal microbes have effect on the infection of ingested pathgens into epithelial cells of mosquito midgut by secreting some proteins or other molecules, thereby regulating the process of pathogen transmission in the mosquito. In this review, we summarize research on the commensal microbes that regulate the transmission of mosquito-borne diseases and understand various mechanisms of commensal microbes involved in the transmission of mosquito-borne pathogens.

Key words: Mosquito microbiota, Mosquito-borne disease, Transmission

CLC Number:

R384.11

Zhen CAI, Xi YU, Gong CHENG. Progress towards mosquito microbiome on regulating the transmission of mosquito-borne diseases[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019, 37(5): 603-608.

References 60

[1]	Backhed F.Host-bacterial mutualism in the human intestine[J]. Science, 2005, 307(5717): 1915-1920.
[2]	刘婧, 陈丹, 庄桂芬, 等. 家蝇发育过程中肠道可培养共生细菌的分离与鉴定[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(2): 120-124.
[3]	Abt MC, Pamer EG.Commensal bacteria mediated defenses against pathogens[J]. Curr Opin Immunol, 2014, 29: 16-22.
[4]	Kane M, Case LK, Kopaskie K, et al. Successful transmission of a retrovirus depends on the commensal Microbiota[J]. Science, 2011, 334(6053): 245-249.
[5]	Dennison NJ, Jupatanakul N, Dimopoulos G.The mosquito Microbiota influences vector competence for human pathogens[J]. Curr Opin Insect Sci, 2014, 3: 6-13.
[6]	Hay SI, Okiro EA, Gething PW, et al. Estimating the global clinical burden of Plasmodium falciparum malaria in 2007[J]. PLoS Med, 2010, 7(6): e1000290.
[7]	Murray NE, Quam MB, Wilder-Smith A.Epidemiology of dengue: past, present and future prospects[J]. Clin Epidemiol, 2013, 5: 299-309.
[8]	Gulland A.Death toll from malaria is double the WHO estimate, study finds[J]. BMJ, 2012, 344: e895.
[9]	张丽, 丰俊, 张少森, 等. 2018年全国疟疾疫情特征及消除工作进展[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(3): 241-247.
[10]	Cheng G, Liu Y, Wang PH, et al. Mosquito defense strategies against Viral infection[J]. Trends Parasitol, 2016, 32(3): 177-186.
[11]	Ramirez JL, Souza-Neto J, Torres Cosme R, et al. Reciprocal tripartite interactions between the Aedes aegypti midgut Microbiota, innate immune system and dengue virus influences vector competence[J]. PLoS Negl Trop Dis, 2012, 6(3): e1561.
[12]	Belkaid Y, Hand TW.Role of the Microbiota in immunity and inflammation[J]. Cell, 2014, 157(1): 121-141.
[13]	Kuss SK, Best GT, Etheredge CA, et al. Intestinal Microbiota promote enteric virus replication and systemic pathogenesis[J]. Science, 2011, 334(6053): 249-252.
[14]	Kane M, Case LK, Kopaskie K, et al. Successful transmission of a retrovirus depends on the commensal Microbiota[J]. Science, 2011, 334(6053): 245-249.
[15]	Fang J.Ecology: A world without mosquitoes[J]. Nature, 2010, 466(7305): 432-434.
[16]	Ricci I, Damiani C, Capone A, et al. Mosquito/Microbiota interactions: from complex relationships to biotechnological perspectives[J]. Curr Opin Microbiol, 2012, 15(3): 278-284.
[17]	Terenius O, Lindh JM, Eriksson-Gonzales K, et al. Midgut bacterial dynamics in Aedes aegypti[J]. FEMS Microbiol Ecol, 2012, 80(3): 556-565.
[18]	王晓明, 吴焜, 陈晓光, 等. 蚊虫共生微生物群多样性及功能的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(3): 305-311.
[19]	Coon KL, Vogel KJ, Brown MR, et al. Mosquitoes rely on their gut Microbiota for development[J]. Mol Ecol, 2014, 23(11): 2727-2739.
[20]	Wang Y, Gilbreath TM, Kukutla P, et al. Dynamic gut microbiome across life history of the malaria mosquito Anopheles gambiae in Kenya[J]. PLoS One, 2011, 6(9): e24767.
[21]	Gimonneau G, Tchioffo MT, Abate L, et al. Composition of Anopheles coluzzii and Anopheles gambiae Microbiota from larval to adult stages[J]. Infect Genet Evol, 2014, 28: 715-724.
[22]	Gusmão DS, Santos AV, Marini DC, et al. Culture-dependent and culture-independent characterization of microorganisms associated with Aedes aegypti (Diptera : Culicidae) (L.) and dynamics of bacterial colonization in the midgut[J]. Acta Trop, 2010, 115(3): 275-281.
[23]	Osei-Poku J, Mbogo CM, Palmer WJ, et al. Deep sequencing reveals extensive variation in the gut Microbiota of wild mosquitoes from Kenya[J]. Mol Ecol, 2012, 21(20): 5138-5150.
[24]	Zouache K, Raharimalala FN, Raquin V, et al. Bacterial diversity of field-caught mosquitoes, Aedes albopictus and Aedes aegypti, from different geographic regions of Madagascar[J]. FEMS Microbiol Ecol, 2011, 75(3): 377-389.
[25]	Boissière A, Tchioffo MT, Bachar D, et al. Midgut Microbiota of the malaria mosquito vector Anopheles gambiae and interactions with Plasmodium falciparum infection[J]. PLoS Pathog, 2012, 8(5): e1002742.
[26]	Favia G, Ricci I, Damiani C, et al. Bacteria of the genus Asaia stably associate with Anopheles stephensi, an Asian malarial mosquito vector[J]. Proc Natl Acad Sci USA, 2007, 104(21): 9047-9051.
[27]	Mancini MV, Damiani C, Accoti A, et al. Estimating bacteria diversity in different organs of nine species of mosquito by next generation sequencing[J]. BMC Microbiol, 2018, 18(1): 126.
[28]	Apte-Deshpande AD, Paingankar MS, Gokhale MD, et al. Serratia odorifera mediated enhancement in susceptibility of Aedes aegypti for chikungunya virus[J]. Indian J Med Res, 2014, 139(5): 762-768.
[29]	Apte-Deshpande A, Paingankar M, Gokhale MD, et al. Serratia odorifera a midgut inhabitant of Aedes aegypti mosquito enhances its susceptibility to dengue-2 virus[J]. PLoS One, 2012, 7(7): e40401.
[30]	Wu P, Sun P, Nie KX, ,et al. A gut commensal Bacterium promotes mosquito permissiveness to Arboviruses[J]. Cell Host Microbe, 2019, 25(1): 101-112.e5.
[31]	Peng J, Zhong JR, Granados R.A baculovirus enhancin alters the permeability of a mucosal midgut peritrophic matrix from lepidopteran larvae[J]. J Insect Physiol, 1999, 45(2): 159-166.
[32]	Fang SL, Wang L, Guo W, et al. Bacillus thuringiensis Bel protein enhances the toxicity of Cry1Ac protein to Helicoverpa armigera larvae by degrading insect intestinal mucin[J]. Appl Environ Microbiol, 2009, 75(16): 5237-5243.
[33]	Marroquín-Cardona AG, Johnson NM, Phillips TD, et al. Mycotoxins in a changing global environment: a review[J]. Food Chem Toxicol, 2014, 69: 220-230.
[34]	Antonissen G, Martel A, Pasmans F, et al. The impact of Fusarium mycotoxins on human and animal host susceptibility to infectious diseases[J]. Toxins (Basel), 2014, 6(2): 430-452.
[35]	Maketon M, Amnuaykanjanasin A, Kaysorngup A.A rapid knockdown effect of Penicillium citrinum for control of the mosquito Culex quinquefasciatus in Thailand[J]. World J Microbiol Biotechnol, 2014, 30(2): 727-736.
[36]	Scholte EJ, Knols BG, Samson RA, et al. Entomopathogenic Fungi for mosquito control: a review[J]. J Insect Sci, 2004, 4: 19.
[37]	Angleró-Rodríguez YI, Talyuli OA, Blumberg BJ, et al. An Aedes aegypti-associated fungus increases susceptibility to dengue virus by modulating gut trypsin activity[J]. Elife, 2017, 6: e28844.
[38]	Ramirez JL, Short SM, Bahia AC, et al. Chromobacterium Csp_P reduces malaria and dengue infection in vector mosquitoes and has entomopathogenic and in vitro anti-pathogen activities[J]. PLoS Pathog, 2014, 10(10): e1004398.
[39]	Saraiva RG, Fang JR, Kang S, et al. Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein[J]. PLoS Negl Trop Dis, 2018, 12(4): e0006443.
[40]	郭秀霞, 王怀位. 蚊虫先天免疫分子机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2015, 33(1): 52-57.
[41]	郑文琪, 苏秀兰. 抗菌肽的抗疟原虫活性及作用机制的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(6): 643-647.
[42]	Blandin S, Levashina EA.Mosquito immune responses against malaria parasites[J]. Curr Opin Immunol, 2004, 16(1): 16-20.
[43]	Dong YM, Morton JC Jr, Ramirez JL, et al. The entomopathogenic fungus Beauveria bassiana activate toll and JAK-STAT pathway-controlled effector genes and anti-dengue activity in Aedes aegypti[J]. Insect Biochem Mol Biol, 2012, 42(2): 126-132.
[44]	Scholte EJ, Knols BG, Takken W.Infection of the malaria mosquito Anopheles gambiae with the entomopathogenic fungus Metarhizium anisopliae reduces blood feeding and fecundity[J]. J Invertebr Pathol, 2006, 91(1): 43-49.
[45]	Jaronski ST.Ecological factors in the inundative use of fungal entomopathogens[J]. Bio Control, 2010, 55(1): 159-185.
[46]	Zimmermann G.Review on safety of the entomopathogenic fungus Metarhizium anisopliae[J]. Biocontrol Sci Technol, 2007, 17(9): 879-920.
[47]	Garza-Hernández JA, Rodríguez-Pérez MA, Salazar MI, et al. Vectorial capacity of Aedes aegypti for dengue virus type 2 is reduced with co-infection of Metarhizium anisopliae[J]. PLoS Negl Trop Dis, 2013, 7(3): e2013.
[48]	Fang WG, Vega-Rodríguez J, Ghosh AK, et al. Development of transgenic Fungi that kill human malaria parasites in mosquitoes[J]. Science, 2011, 331(6020): 1074-1077.
[49]	Thomas MB, Read AF.Can fungal biopesticides control malaria?[J]. Nat Rev Microbiol, 2007, 5(5): 377-383.
[50]	Smith RC, Vega-Rodríguez J, Jacobs-Lorena M.The Plasmodium bottleneck: malaria parasite losses in the mosquito vector[J]. Mem Inst Oswaldo Cruz, 2014, 109(5): 644-661.
[51]	Cirimotich CM, Ramirez JL, Dimopoulos G.Native Microbiota shape insect vector competence for human pathogens[J]. Cell Host Microbe, 2011, 10(4): 307-310.
[52]	Ramirez JL, Dimopoulos G.The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes[J]. Dev Comp Immunol, 2010, 34(6): 625-629.
[53]	Frolet C, Thoma M, Blandin S, et al. Boosting NF-kappaB-dependent basal immunity of Anopheles gambiae aborts development of Plasmodium berghei[J]. Immunity, 2006, 25(4): 677-685.
[54]	Souza-Neto JA, Sim S, Dimopoulos G.An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense[J]. Proc Natl Acad Sci USA, 2009, 106(42): 17841-17846.
[55]	Xi ZY, Ramirez JL, Dimopoulos G.The Aedes aegypti toll pathway controls dengue virus infection[J]. PLoS Pathog, 2008, 4(7): e1000098.
[56]	Meister S, Kanzok SM, Zheng XL, et al. Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae[J]. Proc Natl Acad Sci USA, 2005, 102(32): 11420-11425.
[57]	Garver LS, Bahia AC, Das S, et al. Anopheles Imd pathway factors and effectors in infection intensity-dependent anti-Plasmodium action[J]. PLoS Pathog, 2012, 8(6): e1002737.
[58]	Dostert C, Jouanguy E, Irving P, et al. The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila[J]. Nat Immunol, 2005, 6(9): 946-953.
[59]	Kakumani PK, Ponia SS, Rajgokul KS, et al. Role of RNA interference (RNAi) in dengue virus replication and identification of NS4B as an RNAi suppressor[J]. J Virol, 2013, 87(16): 8870-8883.
[60]	Wang SB, Ghosh AK, Bongio N, et al. Fighting malaria with engineered symbiotic bacteria from vector mosquitoes[J]. Proc Natl Acad Sci USA, 2012, 109(31): 12734-12739.