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Progresses on Antitumor Immune Mechanisms of Protozoon

HUANG Hai-bin，YANG Wen-tao，WANG Chun-feng，YANG Gui-lian*   

  1. College of Animal Science and Technology，Jinlin Agricultural University；Jilin Provincial Engineering Research Center of Animal Probiotics，Changchun 130118，China
  • Online:2015-02-28 Published:2015-05-04
  • Supported by:

    Supported by the National Natural Science Foundation of China（No. 31272552，31272541）and the Hi?鄄tech Research and Development Program of China（No. 2013AA102806，2011AA10A215）

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Abstract:

A variety of protozoons（Amoeba， Trypanosoma cruzi， Eimeria， Plasmodium falciparum and Toxoplasma gondii， etc.） can activate and regulate the human immune system， change tumor-induced immunosuppression， and enhance the anti-tumor immune response. This paper reviews the effects of protozoon on cellular and humoral immunity， the tumor microenvironment in tumor-bearing organisms， and reveals the antitumor immune mechanisms of protozoon.

Key words: Protozoon, Tumor treatment, Cellular immunity, Humoral immunity, Tumor microenvironment