Abstract:

RNA interference（RNAi） technique is a way by which the double-stranded RNA （dsRNA） intermediates the degradation of its homologous mRNA of given gene and specific inhibition of the gene expression subsequently in cells. It is widely applied in functional genomics studies in a wide range of organisms. This paper focuses on its discovery, biological significances, mechanism, and its application as well as the limitations in animal parasitic nematodes.

Key words: RNA interference, Parasitic nematode