Research Progress on the Efficacy， Metabolism and Bioavailability of Mebendazole in Hydatid Disease

›› 2009, Vol. 27 ›› Issue (6): 13-519.

• 综述 • Previous Articles Next Articles

Research Progress on the Efficacy， Metabolism and Bioavailability of Mebendazole in Hydatid Disease

LIU Cong-shan,ZHANG Hao-bing*

National Institute of Parasitic Diseases，Chinese Center for Disease Control and Prevention，Key Laboratory of Parasite and Vector Biology，MOH，WHO Collaborating Centre for Malaria， Schistosomiasis and Filariasis，Shanghai 200025，China

Received:1900-01-01 Revised:1900-01-01 Online:2009-12-30 Published:2009-12-30

Abstract

Abstract: Mebendazole is currently used in the treatment of hydatid disease. Its poor absorption from the gastrointestinal tract and low bioavailability aroused further research on new formulations of mebendazole to increase the bioavailability and improve the therapeutic efficacy. This review summarizes the recent research progress.

Key words: Mebendazole, Pharmacokinetics, Bioavailability, Echinococcus granulosus, Echinococcus multilocularis, Hydatid disease

LIUCong-shan;ZHANGHao-bing*. Research Progress on the Efficacy， Metabolism and Bioavailability of Mebendazole in Hydatid Disease[J]. , 2009, 27(6): 13-519.

[1]	LU Junxia, XU Junying, ZHAO Bin, WANG Qianwen, LI Wenhua, GENG Yuqing, HOU Jun, WU Xiangwei, CHEN Xueling. Echinococcus granulosus infection induces macrophages to express CD73 and A2AR to suppress inflammatory response [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(5): 559-566.
[2]	CAO Deping, LI Jiajing, SONG Mengwei, MO Gang. Experimental observation on the changes of hepatic stellate cells stimulated in vitro with tissue protein of Echinococcus multilocularis [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(4): 440-445.
[3]	WU Xiaoying, HU Yuan, CAO Jianping. Preparation of Echinococcus granulosus peptide embedded in chitosan quaternary ammonium salt nanoparticles [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(3): 300-305.
[4]	LI Benfu, WANG Zhengqing, XU Qian, ZI Jinrong, YAN Xinliu, PENG Jia, LI Jianxiong, CAI Xuan, WU Fangwei, YANG Yaming. Sequence analysis of mitochondrial co1 and nd1 genes in Echinococcus granulosus in Yunnan Province [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(3): 306-311.
[5]	GUO Gang, REN Yuan, JIAO Hongjie, WU Juan, GUO Baoping, QI Wenjing, LI Jun, ZHANG Wenbao. Effect of intraperitoneal inoculation with Echinococcus microcysts on the infection and pathogenicity of E. multilocularis in mouse liver [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(2): 156-162.
[6]	DU Tao, HU Chunhui, GAN Xuehui, GAO Pan, ZHANG Fabin. Anti-Echinococcus multilocularis effect of total alkaloids of Sophora moorcroftiana in water solution and tablet forms in vitro and in vivo [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(1): 15-22.
[7]	JIAO Hongjie, QI Wenjing, GUO Gang, BAO Jianling, WU Chuanchuan, SONG Chuanlong, LI Jun, ZHANG Wenbao, YAN Mei. Polarization effect of Echinococcus granulosus antigen B on the mouse macrophage RAW264.7 [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(1): 23-28.
[8]	HOU Xin-ling, LI De-wei, SHI Yang, WANG Mao-lin, ZIBIGU Rousu, ABIDAN Ainiwaer, ZHENG Xu-ran, KANG Xue-jiao, WANG Hui, LI Jing, ZHANG Chuan-shan. Changes of ST2⁺ T cell subset function and their immune checkpoint molecule expression in the peritoneal cavity of mice infected with Echinococcus multilocularis [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(6): 708-716.
[9]	WU De-fang, FU Yong, REN Bin, ZHANG Yao-gang, XU Xiao-lei, PANG Ming-quan, FAN Hai-ning. Genetic diversity and differentiation time of human isolates of Echinococcus granulosus and E. multilocularis from Qinghai [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(5): 610-615.
[10]	WU Liang-liang, YANG Ling-fei, SONG Tao. Ultrasound and pathological manifestations of lesions in SD rats with hepatic Echinococcus multilocularis infection established by different methods [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(4): 549-552.
[11]	ZHONG Shun-hu, SUN Yue, GUO Xiao-la, ZHENG Ya-dong, CHEN Yi-xia. Identification and bioinformatics analysis of differentially expressed miRNAs in splenic lymphocytes in Echinococcus multilocularis-infected mice [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(3): 288-294.
[12]	ZHUO Yi-cheng, YANG Hai-cheng, LIU Cheng-hao, ZHANG Bao-cai, DUO Xiao-yong, ZHANG Shi-jie. Effect of osteopontin expression level on the growth and development of Echinococcus multilocularis protoscoleces [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(3): 299-304.
[13]	QIAO Shi-yuan, ZHOU Xue, LIU Cheng-hao, JIANG Hui-jiao, BU Yuan-yuan, CHEN Xue-ling, WU Xiang-wei. Effect of albendazole-loaded vesicles on the vitality of protoscoleces of Echinococcus granulosus [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(3): 324-329.
[14]	SUN Ye-ting, JIANG Nan, JIANG Yan-yan, LI Teng, JIANG Xiao-feng, CAO Jian-ping, SHEN Yu-juan. Study on the polarization of MDSC stimulated by Echinococcus granulosus protoscolex-derived exosomes in vitro [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(2): 175-180.
[15]	ABUDUAINI Abulizi, PAIZULA Shalayiadang, TALAITI Tuergan, ZHANG Rui-qing, WANG Hui, ZHANG Chuan-shan, SHAO Ying-mei, TUERGANAILI Aji. Affect of Echinococcus multilocularis protein-mediated NK cell surface receptor NKG2A on the function of NK cells [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(1): 36-42.

Research Progress on the Efficacy， Metabolism and Bioavailability of Mebendazole in Hydatid Disease

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments