›› 2007, Vol. 25 ›› Issue (5): 21-438.

• 研究简报 • Previous Articles     Next Articles

Effects of Fructus psoraleae and Brucea javanica on the Level ofIL-2 and NK cell in Rats Infected with Pneumocystis carinii

DAI Xiao-dong1;QIN Yuan-hua1;ZHOU Chang-hai2;ZHENG Li-li1;SHAO Wei-jun3;TAO Lin1;CUI Yu1   

  1. 1 Department of Parasitology，Dalian Medical University，Dalian 116023，China；2 National Institute of Parasitic Diseases，Chinese Center for Disease Control and Prevention，WHO Cooperation Center for Schisto-somiasis，Malaria and Filariasis，Shanghai 200025，China; 3 Huashan Hospital of Fudan University，Shanghai 200040，China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-30 Published:2007-10-30
  • Contact: CUI Yu

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Abstract: SD rat model of PCP was established by subcutaneous injection with dexamethasone. The treatment groups received Fructus psoraleae（FP， 10.0 mg/kg）， Brucea javanica（BJ， 1.2 mg/kg） and a mixture of the two Chinese herbs（FP 5mg/kg， BJ 0.6 mg/kg） respectively. By means of detecting the level of IL-2 in sera and NK cells in spleens， the effect of FP and BJ on the level of IL-2 and NK cells in rats with Pneumocystis carinii pneumonia （PCP） was observed， with SMZco treatment group （TMP 50 mg/kg， SMZ 250 mg/kg） and groups of infected and normal rats as controls. Compared with the infected group， the level of IL-2（526.1±5.5） pg/ml and NK cells（27.1%±0.8%） significantly increased in the FP group（P<0.01）， followed by the FP/BJ combination group ［（314.7±6.7) pg/ml， 22.9%±0.9%）（P<0.05）］， and BJ group ［（285.4±6.1) pg/ml， 20.7%±1.0%）（P<0.05）］. Chinese herbs Fructus psoraleae and Brucea javanica show an immune regulatory action on the PCP rats.

Key words: Pneumocystis carinii pneumonia, Fructus psoraleae, Brucea javanica, IL-2, NK cell