Abstract: From 2001 to 2003, anti-malarial combination coartem and fansimef, recommended by WHO, were used to treat falciparum malaria in Mali, 28 cases in each group. The mean fever clearance time, mean asexual parasite clearance time and the cure rate in 28 days were 35.3±6.4, 34.7±6.9 hours and 100% respectively in coartem group, and 32.6±5.8, 36.8±5.3 hours and 96.4% respectively in the fansimef group, with no significant difference between the two groups (P>0.05).

Key words: Coartem, Fansimef, Falciparum malaria, Therapy