›› 2006, Vol. 24 ›› Issue (1): 14-62.

• 实验报道 • Previous Articles     Next Articles

Immunological Regulation and Treatment of Brucea javanica and Fructus Psoraleae on Rats with Pneumocystis carinii Pneumonia

QIN Yuan-hua1;CUI Yu1*;REN Yi-xin1;ZHANG Xiao-lin2;WANG Yan2;ZHENG Xiao-yu2;CHEN Xu-wei2;SUN Min2   

  1. 1 Department of Parasitology,Dalian Medical University,Dalian 116023,China; 2 Department of Medicine;Dalian Medical University,Dalian 116023,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2006-02-28 Published:2006-02-28
  • Contact: CUI Yu

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Abstract: Objective To study the imumunological regulation and treatment of Brucea javanica and fructus psoraleae, traditional Chinese medicine, on rats with Pneumocystis carinii pneumonia (PCP). Methods Rats were injected subcutaneously by dexamethasone. When the rats got Pc infected, they were divided into two groups: rats in one group were treated with the mixture of Brucea javanica and fructus psoraleae and another group was used as infected control. Control with normal rats was also established. Observations were made on the number of cysts in lungs and the changes of CD4+ T cells, CD8+ T cells and TNF-α in the serum to demonstrate the imumunological regulation and killing effect of the medicine on cysts in the infected rats. Results The body weight of the rats treated with Brucea javanica and fructus psoraleae increased considerably than that of immunosuppressed rats and the normal control. The damaged lung got improved and repaired, and a significant cyst reduction was shown in the treated group. The CD4+ T cells, CD8+ T cells and level of TNF-α in serum also increased in the treated group significantly. Conclusion The mixture of Brucea javanica and fructus psoraleae plays an imumunological regulation on rats with Pneumocystis carinii pneumonia and shows certain killing effect on the cysts.

Key words: Pneumocystis carinii pneumonia, Brucea javanica, Fructus psoraleae, CD4+ T cell, CD8+ T cells, TNF-α