Abstract: 　Objective] To study the level of five trace elements(Fe 2+ 、Cu 2+ 、Zn 2+ 、Ca 2+ 、Mg 2+ )in the liver, spleen and brain of the rats infected with Toxoplasma gondii. [Methods] 20 rats were randomly and equally divided into two groups: normal group and experimental group. On the 64th day after injection of 1.5×106T.gondii/2 ml, all of the rats were killed and the atomic absorption method were used. [Results] Compared with the normal group, the level of Cu 2+ in liver in experimental group was significantly reduced(P<0 01), and the amount of Fe 2+ of sick rats were higher than that of the normal(P<0 01). No differences in the content of Zn 2+ 、Ca 2+ 、Mg 2+ between the experimental and control group were determined; the level of Fe 2+ 、Cu 2+ in spleen in experimental group was significantly altered(P<0 01). The amount of Mg 2+ of sick rats were higher than that of the normal (P<0 01), and no difference on the content of Zn 2+ 、Ca 2+ between the experimental and control group were estimated;the level of Fe 2+ 、Cu 2+ 、Mg 2+ in brain in experimental group was significantly reduced(P<0 01).The amount of Ca 2+ of sick rats were higher than that of the normal(P<0 02).No difference on the content of Zn 2+ between the experimental and control group were estimated. [Conclusion] T.gondii infection might cause changes in trace elements in the liver,spleen and brain of rats.

Key words: Toxoplasma gondii, liver, spleen, brain, trace element, rat