Abstract: 　Objective To evaluate the specificity and sensitivity of SjMAg in detecting specific antibodies in sera of patients with schistosomiasis japonica and in assessing therapeutic efficacy. [Methods]\ SjMAg-ELISA was used to determine the specific IgG and IgG\-4 in sera of patients with schistosomiasis japonica at different time points after chemotherapy. [Results]\ SjMAg-ELISA was as sensitive and specific as SEA-ELISA. The negative conversion rate of IgG detected by SjMAg-ELISA 12 months after treatment was 80.0%, being significantly higher than 43.3% by SEA-ELISA. The negative conversion rate of IgG\-4 detected by SjMAg-ELISA 12 months after treatment was 93.3%, being significantly higher than 60.0% by SEA-ELISA.The negative conversion rates of IgG and IgG\-4 2 yr after treatment were 92.9% and 97.6% respectively. [Conclusion]\ SjMAg-ELISA is comparable to SEA-ELISA in diagnosing schistosomiasis japonica and is more effective in assessing therapeutic efficacy.\;

Key words: SjMAg, ELISA, evaluation of therapeutic efficacy, antibody detection.