STUDIES ON HUMAN CYTOKINE RESPONSES BEFORE AND AFTER PRAZIQUANTEL CHEMOTHERAPY IN AN ENDEMIC AREA OF SCHISTOSOMIASIS JAPONICA

›› 2000, Vol. 18 ›› Issue (1): 5-17.

STUDIES ON HUMAN CYTOKINE RESPONSES BEFORE AND AFTER PRAZIQUANTEL CHEMOTHERAPY IN AN ENDEMIC AREA OF SCHISTOSOMIASIS JAPONICA

SHEN Lei;WU Hai wei;ZHANG Zhao song;Rosemary Weir;SHAO Li jun;XIE Zhang wu;HU Lin sheng;CHEN Shu zheng;SU Chuan;Taobi Zhang;Martin G Taylor;WU Guan ling

Laboratory of Molecular and Immuno parasitology;Nanjing Medical University;Nanjing 210029

Received:1900-01-01 Revised:1900-01-01 Online:2000-02-28 Published:2000-02-28

Abstract

Abstract: 　Objective] To observe the cellular immune responses in a population of an endemic area of schistosomiasis japonica and the influence of praziquantel treatment.[Methods] Blood was taken from 129 residents (64 cases were egg positive,65 cases were egg negitive) of an endemic area of Poyang Lake before and 45 days after praziquantel treatment. Cytokines induced by the schistosome soluble egg antigen (SEA) and soluble worm antigen preparations (SWAP) in the peripheral blood cells including IL 5, IL 10 and IFN γ were measured. [Results] Among 129 cases, the cytokine levels were found much higher in egg negative individuals than in egg positive individuals.The cytokine levels induced by both antigens were increased significantly after praziqantel treatment especially IL 5 and IFN γ.[Conclusion] The cellular immune responses in the population in schistosomiasis japonica endemic area exhibited a general trend of down regulation and were elevated significantly after praziquantel treatment.

Key words: Schistosomiasis japonica, cellular immune response, treatment, cytokine.

SHENLei;WUHaiwei;ZHANGZhaosong;RosemaryWeir;SHAOLijun;XIEZhangwu;HULinsheng;CHENShuzheng;SUChuan;TaobiZhang;MartinGTaylor;WUGuanling. STUDIES ON HUMAN CYTOKINE RESPONSES BEFORE AND AFTER PRAZIQUANTEL CHEMOTHERAPY IN AN ENDEMIC AREA OF SCHISTOSOMIASIS JAPONICA[J]. , 2000, 18(1): 5-17.

[1]	LEI Jiaxi, GONGSANG Quzhen, WANG Liying, YANG Pin, CHENG Xixi, WANG Zhiyi, JIANG Mingzhe. Cost-effectiveness analysis of population screening and patient treatment for echinococcosis in Xizang from 2015 to 2022 [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025, 43(1): 44-51.
[2]	ZULIPIKAER Tusunniyazi, JIANG Tiemin, WEN Hao. Advances in surgical treatment of hepatic alveolar echinococcosis [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024, 42(6): 783-789.
[3]	XU Kai, CHEN Li, LIN Dengfeng. Advances in the treatment of inflammatory bowel disease with parasites and their agents [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024, 42(3): 407-412.
[4]	XU Yan, WANG Longjiang, KONG Xiangli, LI Yuejin, BU Cancan, YAN Ge, ZHANG Benguang, WANG Yongbin. Epidemiological characteristics of imported malaria in Shandong Province in 2017—2022 [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024, 42(2): 140-146.
[5]	WANG Chunsheng, WU Ergeli, XILIZATI Kulaixi, LI Yuqian, XIANYIDAN Abula, SUBI Tailaiti, PU Xueli, WANG Jialing, LI Meng, FANG Zhiyuan, YE Jianrong. Therapeutic effects of IL-1β receptor blocker on lung injury during the sensitization process of Echinococcus granulosus cyst fluid [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024, 42(2): 199-203.
[6]	Expert Group of National Center for Infectious Diseases, National Center for Infectious Disease Medicine. Expert consensus on diagnosis and treatment of food-borne parasitic diseases (2023) [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(6): 653-668.
[7]	TAN Xiao, ZHU Qi, LIU Zhongqi, LI Jia, PENG Dingjin. Immunogenicity of Schistosoma japonicum Sj26gst mRNA vaccine candidate [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(5): 546-551.
[8]	WANG Denghui, ZHANG Yan, NIE Qiang, LIU Hongwei. A case of Balantidium coli infection [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023, 41(5): 647-649.
[9]	XIAO Chang-lin, YANG Liu-liu, FANG Yong, FENG Xi-lian. A case of pulmonary combined infection of Strongyloides stercoralis with Nocardia otitidiscaviarum [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(6): 810-812.
[10]	Expert Group of National Center for Infectious Diseases. Guidelines for malaria diagnosis and treatment [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(4): 419-427.
[11]	QIAO Fei, LIU Ao, YU Fu-chang, QI Meng. Diagnosis and identification of a case with Taenia saginata infection [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(3): 285-287.
[12]	HE Wei, ZHOU Bi-ying. Research progress on signal pathways related to host T cell immune response in helminth infection [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(2): 223-227.
[13]	ZHAO Zi-qi, LV Fang-li. Research progress on acquired toxoplasmosis in immunocompetent individuals [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(2): 228-235.
[14]	WU Jia-li, LI Bo, LIU Si, TU Zu-wu, TANG Li, TU Zhen, ZHOU Xiao-rong, SUN Ling-cong, XIAO Ying, ZHU Hong. Assessment of transmission risk of human schistosomiasis japonica based on human population antibody level in Hubei Province [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(5): 578-584.
[15]	HUANG Zi-yun, LV Fang-li. Solid organ transplantation and toxoplasmosis [J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(3): 386-392.

STUDIES ON HUMAN CYTOKINE RESPONSES BEFORE AND AFTER PRAZIQUANTEL CHEMOTHERAPY IN AN ENDEMIC AREA OF SCHISTOSOMIASIS JAPONICA

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments