CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES ›› 2022, Vol. 40 ›› Issue (4): 419-427.doi: 10.12140/j.issn.1000-7423.2022.04.001
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Expert Group of National Center for Infectious Diseases*()
Received:
2022-07-12
Revised:
2022-08-01
Online:
2022-08-30
Published:
2022-09-07
Contact:
Expert Group of National Center for Infectious Diseases
E-mail:ljli@zju.edu.cn
CLC Number:
Expert Group of National Center for Infectious Diseases. Guidelines for malaria diagnosis and treatment[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(4): 419-427.
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URL: https://www.jsczz.cn/EN/10.12140/j.issn.1000-7423.2022.04.001
药物名称 | 剂型 | 体质量/kg | 用法用量 | |
---|---|---|---|---|
蒿甲醚/苯芴醇 | 片剂,复方制剂,由蒿甲醚和苯芴醇组成,每片蒿甲醚40 mg + 苯芴醇240 mg | 口服,2次/d,共3 d | ||
5~< 15 | 蒿甲醚20 mg + 苯芴醇120 mg | |||
15~< 25 | 蒿甲醚40 mg + 苯芴醇240 mg | |||
25~< 35 | 蒿甲醚60 mg + 苯芴醇360 mg | |||
≥ 35 | 蒿甲醚80 mg + 苯芴醇480 mg | |||
青蒿琥酯/阿莫地喹 | 片剂,复方制剂,由青蒿琥酯和阿莫地喹组成 国内剂型: 每片青蒿琥酯100 mg+阿莫地喹270 mg 国外剂型还包括: 每片青蒿琥酯25 mg + 阿莫地喹67.5 mg 每片青蒿琥酯50 mg + 阿莫地喹135 mg | 口服,2次/d,共3 d | ||
4.5~< 9 | 青蒿琥酯25 mg + 阿莫地喹67.5 mg | |||
9~< 18 | 青蒿琥酯50 mg + 阿莫地喹135 mg | |||
18~< 36 | 青蒿琥酯100 mg + 阿莫地喹270 mg | |||
≥ 36 | 青蒿琥酯200 mg + 阿莫地喹540 mg | |||
双氢青蒿素/磷酸哌喹 | 片剂,复方制剂,由双氢青蒿素和磷酸哌喹组成 国内剂型: 每片双氢青蒿素40 mg + 磷酸哌喹320 mg 国外剂型还包括: 每片双氢青蒿素20 mg + 磷酸哌喹160 mg | 口服,2次/d,共3 d | ||
5~< 8 | 双氢青蒿素20 mg + 磷酸哌喹160 mg | |||
8~< 11 | 双氢青蒿素30 mg + 磷酸哌喹240 mg | |||
11~< 17 | 双氢青蒿素40 mg + 磷酸哌喹320 mg | |||
17~< 25 | 双氢青蒿素60 mg + 磷酸哌喹480 mg | |||
25~< 36 | 双氢青蒿素80 mg + 磷酸哌喹640 mg | |||
36~< 60 | 双氢青蒿素120 mg + 磷酸哌喹960 mg | |||
60~< 80 | 双氢青蒿素160 mg + 磷酸哌喹1 280 mg | |||
≥ 80 | 双氢青蒿素200 mg + 磷酸哌喹1 600 mg | |||
青蒿琥酯-甲氟喹 | 片剂,联合用药,由青蒿琥酯片和甲氟喹片组合包装 国内无生产厂家 国外剂型包括: 每片青蒿琥酯25 mg + 甲氟喹55 mg 每片青蒿琥酯100 mg + 甲氟喹220 mg | 口服,1次/d,共服3 d | ||
5~< 9 | 青蒿琥酯25 mg + 甲氟喹55 mg | |||
9~< 18 | 青蒿琥酯50 mg + 甲氟喹110 mg | |||
18~< 36 | 青蒿琥酯100 mg + 甲氟喹220 mg | |||
≥ 36 | 青蒿琥酯200 mg + 甲氟喹440 mg | |||
青蒿琥酯-磺胺多辛-乙胺嘧啶 | 联合用药,由青蒿琥酯片和磺胺多辛-乙胺嘧啶(SP)片组合包装由25 mg/片的青蒿琥酯片和500 mg/片磺胺多辛 + 25 mg乙胺嘧啶的SP片组成 | 青蒿琥酯: 口服,1次/d,共服3 d | 磺胺多辛-乙胺嘧啶: 口服,首日单次服用 | |
5~< 10 | 25 mg | 磺胺多辛250 mg + 乙胺嘧啶12.5 mg | ||
10~< 25 | 50 mg | 磺胺多辛500 mg + 乙胺嘧啶25 mg | ||
25~< 50 | 100 mg | 磺胺多辛1 000 mg + 乙胺嘧啶50 mg | ||
≥ 50 | 200 mg | 磺胺多辛1 500 mg + 乙胺嘧啶75 mg | ||
青蒿琥酯-咯萘啶 | 片剂,复方制剂,由青蒿琥酯和磷酸咯萘啶组成 国内无生产厂家 国外剂型包括: 片剂:每片青蒿琥酯60 mg + 磷酸咯萘啶 180 mg | 口服,1次/d,共服3 d | ||
5~< 8 | 青蒿琥酯20 mg + 磷酸咯萘啶60 mg(干混悬剂) | |||
8~< 15 | 青蒿琥酯40 mg + 磷酸咯萘啶120 mg(干混悬剂) | |||
15~< 20 | 青蒿琥酯60 mg + 磷酸咯萘啶180 mg(干混悬剂) | |||
20~< 24 | 青蒿琥酯60 mg + 磷酸咯萘啶180 mg(片剂) | |||
24~< 45 | 青蒿琥酯120 mg + 磷酸咯萘啶360 mg(片剂) | |||
45~< 65 | 青蒿琥酯180 mg + 磷酸咯萘啶540 mg(片剂) | |||
≥ 65 | 青蒿琥酯240 mg + 磷酸咯萘啶720 mg(片剂) |
[1] | World Health Organization. World malaria report 2021[R]. Geneva: WHO, 2021. |
[2] | Gao Q. Challenge and response of imported malaria for preventing malaria re-establishment[J]. Chin Trop Med, 2021, 21(1): 1-4. (in Chinese) |
( 高琪. 输入性疟疾对巩固消除疟疾成果防止再传播的挑战和对策[J]. 中国热带医学, 2021, 21(1): 1-4.) | |
[3] | Feng J, Zhang L, Xia ZG, et al. Malaria elimination in China: an eminent milestone in the anti-malaria campaign and challenges in the post-elimination stage[J]. Chin J Parasitol Parasit Dis, 2021, 39(4): 421-428. (in Chinese) |
( 丰俊, 张丽, 夏志贵, 等. 中国消除疟疾: 重要里程碑意义及消除后的挑战[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(4): 421-428.) | |
[4] | Xia ZG, Zhou SS, Tang LH. History, impacts and experience of malaria elimination in China and strategies and prospects after elimination[J]. Infect Dis Inf, 2022, 35(1): 39-45, 59. (in Chinese) |
( 夏志贵, 周水森, 汤林华. 中国消除疟疾的历程、意义、主要经验及消除后策略与展望[J]. 传染病信息, 2022, 35(1): 39-45, 59.) | |
[5] | Wang XY, Zhang WH. How to strengthen the clinicia’s ability to diagnose and treat malaria after eliminating malaria epidemic in China[J]. J Clin Intern Med, 2022, 39(4): 217-218. (in Chinese) |
( 王新宇, 张文宏. 中国消除疟疾流行后如何加强临床医生疟疾的诊治能力[J]. 临床内科杂志, 2022, 39(4): 217-218.) | |
[6] | Cao J, Liu YB, Cao YY, et al. Sustained challenge to malaria elimination in China: imported malaria[J]. Chin J Parasitol Parasit Dis, 2018, 36(2): 93-96. (in Chinese) |
( 曹俊, 刘耀宝, 曹园园, 等. 中国消除疟疾的持续挑战: 输入性疟疾[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(2): 93-96.) | |
[7] | Feng J, Zhang L, Tu H, et al. From elimination to post-elimination: characteristics, challenges and re-transmission preventing strategy of imported malaria in China[J]. Chin Trop Med, 2021, 21(1): 5-10. (in Chinese) |
( 丰俊, 张丽, 涂宏, 等. 从消除到消除后: 中国输入性疟疾的疫情特征、挑战及防止再传播策略[J]. 中国热带医学, 2021, 21(1): 5-10.) | |
[8] | World Health Organization. WHO guidelines for malaria[M]. Geneva: WHO, 2021. |
[9] | Centers for Disease Control and Prevention. Treatment of malaria: guidelines for clinicians (United States)[EB/OL]. (2020-05-11)[2022-07-01]. https://www.cdc.gov/malaria/resources/pdf/Malaria_Treatment_Guidelines.pdf. |
[10] |
Lalloo DG, Shingadia D, Bell DJ, et al. UK malaria treatment guidelines 2016[J]. J Infect, 2016, 72(6): 635-649.
doi: S0163-4453(16)00047-5 pmid: 26880088 |
[11] | Health Industry Standard of the People’s Republic of China. Diagnosis of malaria: WS 259—2015[S/OL]. (2015-12-01)[2022-06-23]. http://www.nhc.gov.cn/ewebeditor/uploadfile/2015/12/20151208094408183.pdf. (in Chinese) |
(中华人民共和国卫生行业标准. 疟疾的诊断: WS 259—2015[S/OL]. (2015-12-01)[2022-06-23]. http://www.nhc.gov.cn/ewebeditor/uploadfile/2015/12/20151208094408183.pdf. ) | |
[12] | Health Industry Standard of the People’s Republic of China. Specification for use of antimalarial drugs: WS/T 485—2016[S/OL]. (2016-05-01)[2022-06-23]. http://www.nhc.gov.cn/ewebeditor/uploadfile/2016/05/20160530143429328.pdf. (in Chinese) |
(中华人民共和国卫生行业标准. 抗疟药使用规范: WS/T 485—2016[S/OL]. (2016-05-1)[2022-06-23]. http://www.nhc.gov.cn/ewebeditor/uploadfile/2016/05/20160530143429328.pdf. ) | |
[13] | Feng J, Zhang L, Zhang SS, et al. Malaria epidemiological characteristics in China, 2005—2015[J]. Chin Trop Med, 2017, 17(4): 325-335. (in Chinese) |
( 丰俊, 张丽, 张少森, 等. 全国2005—2015年疟疾疫情分析[J]. 中国热带医学, 2017, 17(4): 325-335.) | |
[14] | Tu H, Feng J, Zhang L, et al. The analysis of deaths due to malaria in China, 2016[J]. Chin Trop Med, 2018, 18(7): 650-653. (in Chinese) |
( 涂宏, 丰俊, 张丽, 等. 2016年我国疟疾死亡病例分析[J]. 中国热带医学, 2018, 18(7): 650-653.) | |
[15] | Zhang L, Feng J, Zhang SS, et al. The progress of national malaria elimination and epidemiological characteristics of malaria in China in 2017[J]. Chin J Parasitol Parasit Dis, 2018, 36(3): 201-209. (in Chinese) |
( 张丽, 丰俊, 张少森, 等. 2017年全国消除疟疾进展及疫情特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(3): 201-209.) | |
[16] | Zhang L, Feng J, Zhang SS, et al. Epidemiological characteristics of malaria and the progress towards its elimination in China in 2018[J]. Chin J Parasitol Parasit Dis, 2019, 37(3): 241-247. (in Chinese) |
( 张丽, 丰俊, 张少森, 等. 2018年全国疟疾疫情特征及消除工作进展[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(3): 241-247.) | |
[17] | Zhang L, Feng J, Xia ZG, et al. Epidemiological characteristics of malaria and progress on its elimination in China in 2019[J]. Chin J Parasitol Parasit Dis, 2020, 38(2): 133-138. (in Chinese) |
( 张丽, 丰俊, 夏志贵, 等. 2019年全国疟疾疫情特征分析及消除工作进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(2): 133-138.) | |
[18] | Zhang L, Feng J, Tu H, et al. Malaria epidemiology in China in 2020[J]. Chin J Parasitol Parasit Dis, 2021, 39(2): 195-199. (in Chinese) |
( 张丽, 丰俊, 涂宏, 等. 2020年全国疟疾疫情分析[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(2): 195-199.) | |
[19] | Zhang L, Yi BY, Xia ZG, et al. Epidemiological characteristics of malaria in China, 2021[J]. Chin J Parasitol Parasit Dis, 2022, 40(2): 135-139. (in Chinese) |
( 张丽, 易博禹, 夏志贵, 等. 2021年全国疟疾疫情特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(2): 135-139.) | |
[20] | Jiang XH, Huang YX, Ling Y, et al. Clinical epidemiological analysis of imported malaria in Shanghai[J]. Chin J Parasitol Parasit Dis, 2017, 35(2): 150-155. (in Chinese) |
( 蒋旭华, 黄玉仙, 凌云, 等. 上海市输入性疟疾临床流行病学特征分析[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(2): 150-155.) | |
[21] | Wang XY, Yang LL, Jiang T, et al. Effects of a malaria elimination program: a retrospective study of 623 cases from 2008 to 2013 in a Chinese County hospital near the China-Myanmar border[J]. Emerg Microbes Infect, 2016, 5(1): e6. |
[22] |
WHO. Severe malaria[J]. Trop Med Int Health, 2014, 19(Suppl 1): 7-131.
doi: 10.1111/tmi.12313_2 |
[23] | Yang YJ. Research on severe cases of imported falciparum malaria[J]. Chin Trop Med, 2018, 18(7): 662-665. (in Chinese) |
( 杨跃杰. 输入性恶性疟疾重症病例研究[J]. 中国热带医学, 2018, 18(7): 662-665.) | |
[24] | He ZY, Wu WT, Wang XM, et al. Analysis on the characteristics and risk factors of imported malaria deaths in Beijing[J]. Acta Parasitol Med Entomol Sin, 2021, 28(2): 67-70, 75. (in Chinese) |
( 何战英, 吴文婷, 王小梅, 等. 北京市输入性疟疾死亡病例特征及危险因素分析[J]. 寄生虫与医学昆虫学报, 2021, 28(2): 67-70, 75.) | |
[25] |
Zhang Q, Geng QB, Sun JL, et al. Epidemiological analysis of the deaths of malaria in China, 2005—2014[J]. Chin J Prev Med, 2016, 50(4): 302-305. (in Chinese)
doi: 10.3760/cma.j.issn.0253-9624.2016.04.004 pmid: 27029359 |
( 张倩, 耿启彬, 孙军玲, 等. 2005—2014年中国疟疾死亡病例流行特征分析[J]. 中华预防医学杂志, 2016, 50(4): 302-305.) | |
[26] | Su Y, Miao Q, Hu BJ, et al. A case of Plasmodium malariae infection identified by metgenomic next-generation sequencing and literature review[J]. Chin J Clin Infect Dis, 2019, 12(5): 359-361. (in Chinese) |
( 苏逸, 缪青, 王青青, 等. 宏基因二代基因检测技术诊断三日疟一例及文献复习[J]. 中华临床感染病杂志, 2019, 12(5): 359-361.) | |
[27] | Li RQ, Wang XM, Sun YL, et al. Application of metagenomic next-generation sequencing in the diagnosis of imported malaria[J]. Chin J Parasitol Parasit Dis, 2019, 37(6): 727-729. (in Chinese) |
( 李仁清, 王小梅, 孙玉兰, 等. 宏基因组学二代测序技术在输入性疟疾诊断中的应用[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(6): 727-729.) | |
[28] | Zhou SS. Problems in the use of antimalarial drugs and their impacts on malaria elimination in China[J]. Chin Trop Med, 2018, 18(7): 640-642. (in Chinese) |
( 周水森. 我国抗疟药使用存在的问题及其对消除疟疾的影响[J]. 中国热带医学, 2018, 18(7): 640-642.) | |
[29] |
Yu FT, Zhang SF, Chen BH, et al. Evaluation of the diagnostic accuracy of the CareStartTM glucose-6-phosphate dehydrogenase deficiency rapid diagnostic test among Chinese newborns[J]. J Trop Pediatr, 2020, 66(5): 495-503.
doi: 10.1093/tropej/fmaa003 |
[30] | Hua HY, Sun F, Chen W, et al. Interpretation of WHO management of severe malaria(third edition)[J]. Chin Trop Med, 2018, 18(7): 643-645, 649. (in Chinese) |
华海涌, 孙芳, 陈伟, 等. 世界卫生组织《重症疟疾管理实用手册》(第三版)解读[J]. 中国热带医学, 2018, 18(7):643- 645, 649.) | |
[31] |
Wooldridge G, Nandi D, Chimalizeni Y, et al. Cardiovascular findings in severe malaria: a review[J]. Glob Heart, 2020, 15(1): 75.
doi: 10.5334/gh.789 pmid: 33299771 |
[32] | Phu NH, Day NPJ, Tuan PQ, et al. Concomitant bacteremia in adults with severe falciparum malaria[J]. Clin Infect Dis, 2020, 71(9): e465-e470. |
[33] | Liu YY, Lian JS, Huang JR. Two cases of malignant malaria complicated with hemolytic uremic syndrome were treated with blood purification[J]. Chin J Infect Dis, 2016, 34(9): 570. (in Chinese) |
( 刘月英, 连江山, 黄建荣. 血液净化治疗恶性疟疾并发溶血尿毒综合征二例[J]. 中华传染病杂志, 2016, 34(9): 570.) |
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