Abstract: 　AIM: To study the immunoregulation of IL-2 in Trichinella-infected mice. METHODS: Mice infected respectively with HL strain and AM strain larvae of Trichinella spiralis were treated ip with IL-2 from the second day postinfection for 3 days. Serum IgG antibody levels were determined by ELISA and the infection capacity was determined using reproductive capacity index (RCI). RESULTS: In HL, higher dosage of IL-2 injection induced lower RCI and showed apparent anti-Trichinella effect. In AM, both low and high dose of IL-2 had no measurable effect on RCI, however, high dose of IL-2 reduced the infectivity of newborn larvae. CONCLUSION: IL-2 exhibits apparent suppressive effect on the infectivity of T.spiralis of HL strain.\;

Key words: Trichinellosis, mouse, interleukin-2, IgG