›› 1998, Vol. 16 ›› Issue (4): 251-255.

• 论著 • Previous Articles     Next Articles

EFFECT OF TESTOSTERONE ON LEISHMANIA DONOVANI INFECTION LEVELS OF MURINE BONE MARROW DERIVED MACROPHAGES

Yin Guorong 1; Guo Zhiyong 2; Yin Lei 2; Zhao Jiahui 2; Qiao Zhongdong 2 **; Frank Wunderlich 3

  

  1. 1 Division of Parasitology of Shanxi Medical University; Taiyuan 030001 2 Laboratory of Molecular Biology of Shanxi Medical University; Taiyua; 3 Division of Molecular Parasitology , Heinrich-Heine University, 40225 Duesseldorf, Germany
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-08-28 Published:1998-08-28

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Abstract: AIM: To investigate the effect of the male sex hormone, testosterone (Te), on Leishmania donovani infection levels of bone marrow derived macrophages(BMMs) from female mice of strain C57BL/6J. METHODS: After three weeks of Te treatment, the BMMs were isolated, challenged with L.donovani at a ratio of 10 to 1 promastigotes per macrophage, and the infection levels of different time points were monitored by Giemsa staining. RESULTS: BMMs from Te treated mice had a significantly increased initial uptake(3 h post infection, P < 0.05) of promastigotes and carried heavier infection levels at all time points (24 h, 48 h, 72 h post infection, P< 0.01) , compared with those from oil treated controls. CONCLUSION: Te can increase L. donovani infection levels of BMMs, being possibly related to Te-induced immuno suppression.

Key words: BMMs, L.donovani, testosterone, immunosuppression