Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection

doi:10.12140/j.issn.1000-7423.2021.04.014

Abstract

Abstract:

Myeloid-derived suppressor cells (MDSCs) are a group of immature heterogeneous myeloid cells, which are the precursors of dendritic cells, macrophages, and granulocytes. These precursor cells can be recruited to microenvironments, such as lymph nodes, spleen, peripheral blood and tumor, under pathological conditions, where they are further activated. After activation, MDSCs can suppress T cell immune response through various mechanisms, which are widely involved in different stages of parasitic infection. This review summarizes the research progress on the immunosuppressive function of MDSCs in the field of parasitic infection.

Key words: Myeloid-derived suppressor cells, Immunosuppression, Parasitic infection

CLC Number:

SUN Ye-ting, CAO Jian-ping, SHEN Yu-juan. Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021, 39(4): 505-513.

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