Abstract: AIM: For the purpose of finding an anthelmintic with high efficacy,low toxicity and low cost,
especially from the Chinese tranditional medicines. METHODS:Forty Cysticercus cellulosae were separately
incubated with proteinase from artificially fermented Omphalia lapidescens for 2 h, 4 h and 8 h, and then
examined for histological changes by light microscopy and compared with those of proteinase from natural dry
Omphalia lapidescens after similar treatment.RESULTS: Cysticercus cellulosae were mo rphologically and structurally impaired after exposure to the action of proteinase of Omphalia lapidescens, and the degree of impairment was proportionally paralleled to the duration of treatment. CONCLUSION: The anticysticercus effect of proteinase of Omphalia lapidescens and the homogeneity of proteinases from artificially fermented and natural Omphalia lapidescens were confirmed.

Key words: Artificially fermented, Omphalia lapidescens, Cysticercus cellulosae, histopathology