AIM: To demonstrate the effect of alcoholic extract of Buthus martensii against Cysticercus cellulosae in vitro. METHODS: Fresh Cysticercus cellulosae were cultured in 15% swine bile medium containing scorpio alcoholic extract. RESULTS: The scorpio extract at 26mg/ml exerted profound effect in destroying cysticerci as assessed by the morphological changes and loss of vitality. After of the Cysticercus cellulosae were cultured in medium containing scorpio extract for 4, 6 and 8 hours, evident pathological changes were revealed. The main microscopic features were peeling of microtriches, swelling, and deformity of rostellum and suckers of evaginated cysticerci. CONCLUSION: Scorpion extract exerts damage effect on both the tegument and scolex of Cysticercus celluosae.