Abstract: The rates of parasitemias were compared by using the same strain of Plasmodium falciparum cultivated continuously with various ABO group erythrocytes in vitro. The results showed that erythrocytes of four blood groups were sensitive to P. falciparum. However, when the samples were determined on the seventh day (D6) in the short-term cultivation, the rate of parasitemia of B group erythrocytes was the highest, while that of O group erythrocytes was the lowest. The difference between them was statistically significant, and the parasitemias of A and AB groups erythrocytes were of intermediate rates. Mixed blood and the blood in which the ABO group erythrocytes were changed frequently had no obvious influence on the growth of P. falciparum in the continuous cultivation.