Research progress on the role of pyroptosis in human parasitic diseases

doi:10.12140/j.issn.1000-7423.2022.06.014

Abstract

Abstract:

Pyroptosis is a new type of death mode found in recent years, which depends on caspase. Activated caspase breaks the cell membrane by cutting gasdermin protein, and at the same time, it releases pro-inflammatory cytokines and their contents, eventually leading to cell death. Its occurrence, morphological characteristics and regulatory mechanism are different from cell death modes such as apoptosis, necrosis, autophagy and iron death. Pyroptosis signal pathways include classical pathway, non-classical pathway and other pathways. At present, many studies have confirmed that pyroptosis is involved in the development of parasitic diseases. This article reviews the definition of pyroptosis, different pathways and mechanisms, and their roles in various Human parasitic diseases, hoping to provide a basis for developing the research between pyroptosis and parasitic diseases.

Key words: Pyroptosis, Gasdermin protein, Caspase, Nod-like receptor protein 3, Human parasitic disease

CLC Number:

NIE Ru, LI Wen-deng, YE Geng-bo, YIN Feng-jiao, PANG Ming-quan, WANG Zhi-xin, FAN Hai-ning. Research progress on the role of pyroptosis in human parasitic diseases[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(6): 780-785.

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