弓形虫钙离子结合蛋白的研究进展

中国寄生虫学与寄生虫病杂志 ›› 2018, Vol. 36 ›› Issue (5): 525-528.

弓形虫钙离子结合蛋白的研究进展

赵旭, 张婷, 张义伟, 王大为, 冯颖, 杨娜, 陈冉, 桑晓宇, 陈启军, 姜宁^*()

沈阳农业大学畜牧兽医学院,辽宁省重点实验室,沈阳100886

收稿日期:2018-03-21 出版日期:2018-10-30 发布日期:2018-11-13
通讯作者: 姜宁
基金资助:
吉林省省级经济结构调整战略调整引导资金专项项目（No. 2015Y033）

Research progress on calcium-binding protein in Toxoplasma gondii

Xu ZHAO, Ting ZHANG, Yi-wei ZHANG, Da-wei WANG, Ying FENG, Na YANG, Ran CHEN, Xiao-yu SANG, Qi-jun CHEN, Ning JIANG^*()

Animal Husbandry and Veterinary College, Shenyang Agricultural University, Key Laboratory of Liaoning Province, Shenyang 100886, China

Received:2018-03-21 Online:2018-10-30 Published:2018-11-13
Contact: Ning JIANG
Supported by:
Supported by Special Project for Economic Structure Strategic Adjustment and Guiding Fund of Jilin Province（No. 2015Y033）

摘要/Abstract

摘要：

刚地弓形虫（Toxoplasma gondii）作为顶复门中一种寄生原虫,可以感染有核细胞。研究表明,钙离子与弓形虫侵染、运动等生理活动相关。内质网中含有大量的钙离子,许多钙离子结合蛋白质在弓形虫的生理活动中起重要作用。钙离子结合蛋白质包含多种EF手型（EF-hand）结构域。目前记载在TOXO DB中含有EF-hand的蛋白质有55种;在Plasmo DB含有EF-hand的蛋白质有69种。本文对钙离子结合蛋白质的各种作用进行阐述。

关键词: 刚地弓形虫, 顶复门, 钙离子结合蛋白质

Abstract:

Toxoplasma gondii, a type of apicomplexa protozoan parasite, can infect nucleated cells. Studies have shown that Ca²⁺ is associated with physiological activity of Toxoplasma gondii such as infection and movement. Ca²⁺ is abundant in endoplasmic reticulum. There are many calcium-binding proteins important for physiological activity of Toxoplasma gondii. The calcium-binding proteins contain various EF-hand （EF） motifs, and currently there are 55 such proteins according to the records in Toxo DB, and 69 in Plasmo DB. In this review, the roles of Ca²⁺-binding proteins are discussed.

Key words: Toxoplasma gondii, Apicomplexa, Calcium-binding protein

中图分类号:

R383.3

赵旭, 张婷, 张义伟, 王大为, 冯颖, 杨娜, 陈冉, 桑晓宇, 陈启军, 姜宁. 弓形虫钙离子结合蛋白的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(5): 525-528.

Xu ZHAO, Ting ZHANG, Yi-wei ZHANG, Da-wei WANG, Ying FENG, Na YANG, Ran CHEN, Xiao-yu SANG, Qi-jun CHEN, Ning JIANG. Research progress on calcium-binding protein in Toxoplasma gondii[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(5): 525-528.

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