疟原虫内膜复合体蛋白研究进展

doi:10.12140/j.issn.1000-7423.2024.01.016

摘要/Abstract

摘要：

疟疾是由疟原虫感染所致的全球危害最严重的三大传染病之一。疟原虫的裂殖子、动合子和子孢子均具有特征性的内膜复合体（IMC）。IMC定位于质膜下，在胞质侧与膜下网络紧密相连。IMC在细胞分裂过程中提供支撑骨架，维持细胞的形态和稳定性，参与疟原虫发育和入侵宿主细胞等过程。深入研究IMC蛋白的结构、功能和转录调控机制，对研发相应的抑制剂或阻断剂以阻断疟疾传播有重要意义。本文就近年来IMC蛋白结构及其转录调控机制的研究进展进行综述。

关键词: 疟原虫, 内膜复合体, 肺泡蛋白, 棕榈酰化, 磷酸化

Abstract:

Malaria is one of the world’s three most serious infectious diseases which caused by Plasmodium spp. The Plasmodium merozoite, ookinete, and sporozoite all have characteristic endomembrane complexes (IMCs). IMC is localized under the plasma membrane and is closely linked to the subpellicular protein network on the cytoplasmic side of the membrane. IMC is involved in the parasite development and invasion of the host cells by providing a support backbone during cell division, maintaining cell morphology and stability. In-depth studies of the structure, function and transcriptional regulation mechanism of IMC protein are of great significance for the development of corresponding inhibitors or blockers to block malaria transmission. In this paper, we reviewed the research progress of IMC protein structure and transcriptional regulation mechanisms in recent years.

Key words: Plasmodium, Inner membrane complex, Alveolins, Palmitoylation, Phosphorylation

中图分类号:

R382.31

韩竹茜, 朱晓彤. 疟原虫内膜复合体蛋白研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(1): 111-116.

HAN Zhuxi, ZHU Xiaotong. Research progress on Plasmodium membrane protein complexes[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2024, 42(1): 111-116.

图/表 1

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蛋白名称	基因编号		参考文献
蛋白名称	恶性疟原虫	伯氏疟原虫	参考文献
IMC1a/ALV1	PF3D7_0304000	PBANKA_040260	[7-8]
IMC1b	PF3D7_1141900	PBANKA_090710	[13]
IMC1c/ALV5	PF3D7_1003600	PBANKA_120200	[14-15]
IMC1d	PF3D7_0708600	PBANKA_121910	[20]
IMC1e/ALV2	PF3D7_0304100	PBANKA_040270	[6,14]
IMC1f/ALV6	PF3D7_1351700	PBANKA_136440	[20]
IMC1g/ALV4	PF3D7_0525800	PBANKA_124060	[6]
IMC1h/ALV3	PF3D7_1221400	PBANKA_143660	[17⇓-19]
IMC1i	PF3D7_0823500	PBANKA_070710	[22]
IMC1j/ALV7	PF3D7_0621400	PBANKA_112040	[6,22]
IMC1k	PF3D7_1341800	PBANKA_135490	[20,22]
IMC1l	PF3D7_1417000	PBANKA_102570	[20-21]
IMC1m	PF3D7_1028900	PBANKA_051300	[20,22]