慢性弓形虫感染对宿主中枢神经系统的损伤及其作用机制

doi:10.12140/j.issn.1000-7423.2023.05.001

摘要/Abstract

摘要：

刚地弓形虫是一种在世界范围内广泛分布的专性细胞内寄生原虫，可引起人兽共患弓形虫病。脑内弓形虫感染可导致中枢神经系统病变，引起抑郁症、精神分裂症、癫痫等症状。本文就弓形虫通过血脑屏障建立慢性感染，引起中枢神经系统损伤和脑部疾病的机制进行综述。

关键词: 刚地弓形虫, 中枢神经系统, 慢性感染

Abstract:

Toxoplasma gondii is an obligate intracellular parasite that widely distributes in the world and causes zoonotic toxoplasmosis. In recent years, parasite infection in the brain has been paid more and more attention. T. gondii can cause central nervous system damage, often manifested as depression, schizophrenia, epilepsy and other symptoms. In this paper, the process and mechanism of T. gondii establishing chronic infection through blood-brain barrier, causing central nervous system injury and disease are reviewed.

Key words: Toxoplasma gondii, Central nervous system, Chronic infection

中图分类号:

R382.5

薛羽珊, 林萍, 程训佳, 冯萌. 慢性弓形虫感染对宿主中枢神经系统的损伤及其作用机制[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(5): 527-531.

XUE Yushan, LIN Ping, CHENG Xunjia, FENG Meng. Damage caused by chronic infection of Toxoplasma gondii on the host central nervous system and its mechanism[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(5): 527-531.

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