非编码RNA在利什曼病中的调控作用研究进展

doi:10.12140/j.issn.1000-7423.2023.01.014

中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (1): 92-97.doi: 10.12140/j.issn.1000-7423.2023.01.014

非编码RNA在利什曼病中的调控作用研究进展

蒋天哥¹(), 曾文博², 李中秋², 张仪¹^,²^,^*()

1.上海交通大学医学院-国家热带病研究中心全球健康学院，上海 200025
2.中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)，国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，国家级热带病国际联合研究中心，上海 200025

收稿日期:2022-04-27 修回日期:2022-06-29 出版日期:2023-02-28 发布日期:2023-02-24
通讯作者: * 张仪（1966-），女，研究员，从事病原生物学、媒介生物学、媒介生物学与控制、医学寄生虫学等方面的研究。E-mail：zhangyi@nipd.chinacdc.cn
作者简介:蒋天哥（1998-），女，硕士研究生，从事全健康和传染病研究。E-mail：J_Tiane@163.com
基金资助:
上海市青年科技英才扬帆计划(21YF1452200);国家科技基础资源调查专项(2017FY101203)

Research advances in the regulatory role of non-coding RNA in leishmaniasis

JIANG Tiange¹(), ZENG Wenbo², LI Zhongqiu², ZHANG Yi¹^,²^,^*()

1. School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
2. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research); NHC Key Laboratory of Parasite and Vector Biology; WHO Collaborating Center for Tropical Diseases; National Center for International Research on Tropical Diseases, Shanghai 200025, China

Received:2022-04-27 Revised:2022-06-29 Online:2023-02-28 Published:2023-02-24
Contact: * E-mail: zhangyi@nipd.chinacdc.cn
Supported by:
Shanghai Sailing Program(21YF1452200);National Science and Technology Basic Resources Survey Special Project(2017FY101203)

摘要/Abstract

摘要：

利什曼原虫可寄生于人或动物的巨噬细胞中，其引起的利什曼病是一种被忽视的热带病，据估计每年死亡人数高达4万人。非编码RNA（ncRNA）是一种不被翻译成蛋白质的基因组转录本，在多种疾病的发生发展过程中起重要的调控作用，在炎症和免疫应答中尤其突出。目前对于ncRNA在利什曼病中作用机制的研究相对较少，已有的研究表明，在利什曼原虫感染宿主初期，ncRNA通过调节抗原呈递、免疫应答、细胞自噬、细胞凋亡等过程，对原虫在宿主体内的增殖和感染起调节作用。本文对ncRNA在利什曼病中的作用机制进行综述，为利什曼病的预防、诊断和治疗提供参考。

关键词: 利什曼病, 非编码RNA, 免疫应答, 作用机制

Abstract:

Leishmania, which can parasitize in the macrophages of humans and animals, causing leishmaniasis, a neglected tropical disease that is estimated to kill up to 40 000 people each year. Non-coding RNA (ncRNA) is a genomic transcript that is not translated into proteins, and plays an important regulatory role in the occurrence and development of a variety of diseases, especially in inflammatory and immune responses. At present, there are few studies on the mechanism of action of ncRNA in leishmaniasis, and the existing studies have shown that in the early stage of Leishmania infection with the host, ncRNA plays an important regulatory role in regulating the proliferation of the parasites in the host and the establishment of infection by regulating antigen presentation, immune response, autophagy, apoptosis. This article reviews the mechanism of action of ncRNA in leishmaniasis, which is critical for the prevention, diagnosis and treatment of leishmaniasis.

Key words: Leishmaniasis, Non-coding RNA, Immune response, Mechanism

中图分类号:

R531.6

蒋天哥, 曾文博, 李中秋, 张仪. 非编码RNA在利什曼病中的调控作用研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(1): 92-97.

JIANG Tiange, ZENG Wenbo, LI Zhongqiu, ZHANG Yi. Research advances in the regulatory role of non-coding RNA in leishmaniasis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(1): 92-97.

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非编码RNA在利什曼病中的调控作用研究进展

Research advances in the regulatory role of non-coding RNA in leishmaniasis

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