河南省内脏利什曼病流行病学特征和时空聚类分析

doi:10.12140/j.issn.1000-7423.2024.03.009

中国寄生虫学与寄生虫病杂志 ›› 2024, Vol. 42 ›› Issue (3): 340-344.doi: 10.12140/j.issn.1000-7423.2024.03.009

河南省内脏利什曼病流行病学特征和时空聚类分析

杨成运¹(), 王丹¹, 贺志权¹, 纪鹏慧¹, 鲁德岭¹, 周正斌², 钱丹¹, 刘颖¹, 李素华¹, 周瑞敏¹, 邓艳¹, 张红卫¹^,^*()

1 河南省疾病预防控制中心寄生虫病预防控制所，河南省寄生虫病原与媒介医学重点实验室，郑州 450016
2 中国疾病预防控制中心寄生虫病预防控制所（国家热带病研究中心），传染病溯源预警与智能决策全国重点实验室，国家卫生健康委员会寄生虫病原与媒介生物学重点实验室，世界卫生组织热带病合作中心，科技部国家级热带病国际研究中心，上海 200025

收稿日期:2023-11-03 修回日期:2024-02-04 出版日期:2024-06-30 发布日期:2024-07-16
通讯作者: *张红卫（1969—），男，博士，主任医师，从事寄生虫病防治研究。E-mail：zhwei69@163.qq.com
作者简介:杨成运（1975—），女，博士，副主任技师，从事寄生虫病防治研究。E-mail：tochyun@163.com
基金资助:
河南省科技攻关项目(222102310722);河南省科技攻关项目(242102310214);河南省医学科技攻关计划联合共建项目(LHGJ20220171);河南省医学科技攻关计划联合共建项目(LHGJ20230640)

Epidemiological characteristics and spatio-temporal clustering of visceral leishmaniasis in Henan Province

YANG Chengyun¹(), WANG Dan¹, HE Zhiquan¹, JI Penghui¹, LU Deling¹, ZHOU Zhengbin², QIAN Dan¹, LIU Ying¹, LI Suhua¹, ZHOU Ruimin¹, DENG Yan¹, ZHANG Hongwei¹^,^*()

1 Institution of Parasite Disease Control and Prevention, Henan Provincial Center for Disease Control and Prevention; Henan Provincial Medical Key Laboratory of Parasitic Pathogen and Vector, Zhengzhou 450016, China
2 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory on Parasite and Vector Biology, Ministry of Health; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China

Received:2023-11-03 Revised:2024-02-04 Online:2024-06-30 Published:2024-07-16
Supported by:
Science and Technology of Henan Province(222102310722);Science and Technology of Henan Province(242102310214);Joint Project of Medical Science and Technology of Henan Province(LHGJ20220171);Joint Project of Medical Science and Technology of Henan Province(LHGJ20230640)

摘要/Abstract

摘要：

目的分析河南省内脏利什曼病（VL）流行病学特征和时空聚类，为疫情监测和精准防控措施的制定提供理论依据。方法收集2016—2022年国家传染病报告信息管理系统中报告的河南省VL病例资料，对VL流行病学特征进行描述性分析。应用SaTScan v10.1软件进行时空聚类分析。结果 2016—2022年河南省报告VL病例68例，年均发病率为0.010/10万，呈现逐年上升趋势（χ² = 5.206，P < 0.05）。除8月外，2016—2022年每月均有病例报告，报告高峰期为3—6月，占报告病例总数的50.0%（34/68）。报告病例的男女性别比为2.6∶1，男性和女性的年均发病率分别为0.011/10万和0.004/10万（χ² = 2.400，P > 0.05）。报告病例年龄范围为7个月至71岁，0~2岁组和≥ 60岁组分别占27.9%（19/68）和25.0%（17/68）。职业分布以农民（42.7%，29/68）和散居儿童（32.4%，22/68）为主。68例报告病例中本地感染61例、外省输入7例，61例本地感染病例分布在郑州市、洛阳市、安阳市、鹤壁市和三门峡市等5个地级市的13个县（市、区）。时空聚类分析结果显示2个有意义的聚集区域，聚集中心分别为安阳市林州市和郑州市巩义市。结论 2016年以来河南省VL的流行整体呈上升态势，且具有时空聚集性，需要对不同流行程度的流行区开展精准监测和防控，防止疫情继续扩散。

关键词: 内脏利什曼病, 流行特征, 时空聚类, 河南省

Abstract:

Objective To analyze the epidemiological characteristics and spatio-temporal clustering of visceral leishmaniasis (VL) in Henan Province, and provide a theoretical basis for epidemic surveillance and formulating precise prevention and control measures. Methods The data on VL cases reported in Henan Province were collected from the Infectious Disease Surveillance Reporting and Management System from 2016 to 2022. The epidemiological characteristics of VL repored cases were analyzed using descriptive analysis. SaTScan v10.1 software was used for spatio-temporal clustering analysis. Results A total of 68 VL cases were reported in Henan Province from 2016 to 2022, with an annual average incidence rate of 0.010/100 000 showing an increasing trend year by year (χ² = 5.206, P < 0.05). The cases were reported throughout the year except for August, and the peak period of onset was from March to June, accounting for 50.0% (34/68) of reported cases. The ratio of males and females was 2.6 ∶ 1, and the annual average incidence rates in males and females were 0.011/100 000 and 0.004/100 000, respectively. The age range of reported cases was from 7 months to 71 years old. The majority of patients were in the 0-2 group and the ≥ 60 years age groups, accounting for 27.9% (19/68) and 25.0% (17/68), respectively. Farmers (42.7%, 29/68) and scattered resident children (32.4%, 22/68) were the dominant high-risk population. Among the 68 reported cases, 61 were local cases and 7 were imported from other provinces. The 61 local cases were distributed in 13 counties (cities, districts) among 5 provincial-level cities, including Zhengzhou, Luoyang, Anyang, Hebi and Sanmenxia. The results of spatio-temporal clustering analysis showed that two significant clustering regions (P < 0.01) were detected for VL in Henan Province, with the clustering centres being Linzhou in Anyang City and Gongyi in Zhengzhou City, respectively. Conclusion VL had been on the rise in Henan Province, with spatial-temporal clustering. It is necessary to carry out precise surveillance and implement prevention and control measures in different epidemic areas to prevent the ongoing spread of the epidemic.

Key words: Visceral leishmaniasis, Epidemic characteristics, Spatio-temporal clustering, Henan Province

中图分类号:

R531.6

杨成运, 王丹, 贺志权, 纪鹏慧, 鲁德岭, 周正斌, 钱丹, 刘颖, 李素华, 周瑞敏, 邓艳, 张红卫. 河南省内脏利什曼病流行病学特征和时空聚类分析[J]. 中国寄生虫学与寄生虫病杂志, 2024, 42(3): 340-344.

YANG Chengyun, WANG Dan, HE Zhiquan, JI Penghui, LU Deling, ZHOU Zhengbin, QIAN Dan, LIU Ying, LI Suhua, ZHOU Ruimin, DENG Yan, ZHANG Hongwei. Epidemiological characteristics and spatio-temporal clustering of visceral leishmaniasis in Henan Province[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2024, 42(3): 340-344.

图/表 4

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参考文献 24

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特征 Feature	报告病例数/例 No. reported case	构成比/% Composition rate/%
性别 Gender
男 Male	49	72.1
女 Female	19	27.9
年龄组/岁 Age group/Year
0~2	19	27.9
3~9	8	11.8
10~19	2	2.9
20~29	0	0
30~39	5	7.4
40~49	11	16.2
50~59	6	8.8
≥ 60	17	25.0
职业 Occupation
干部职员 Official	2	2.9
家务及待业 Housework and unemployment	6	8.8
牧民 Herdsman	1	1.5
农民 Farmer	29	42.6
散居儿童 Scattered child	22	32.4
商业服务 Business service	1	1.5
学生 Student	4	5.9
幼托儿童 Child care	3	4.4
合计 Total	68	100.0

年份 Year	地级市 Prefecture-level city	流行县（报告病例数/例） Endemic county (No. reported case)
2016	安阳 Anyang	林州市 Linzhou City (2)
2017	安阳 Anyang	林州市 Linzhou City (2)
2018	安阳 Anyang	林州市 Linzhou City (2)
2019	安阳 Anyang	林州市 Linzhou City (2), 龙安区 Long’an District (1)
2020	安阳 Anyang	林州市 Linzhou City (5)
	郑州 Zhengzhou	巩义市 Gongyi City (3), 登封市 Dengfeng City (2), 荥阳市 Xingyang City (1)
	洛阳 Luoyang	新安县 Xin’an County (1), 孟津区 Mengjin District (1), 涧西区 Jianxi District (1)
2021	安阳 Anyang	林州市 Linzhou City (7)
	郑州 Zhengzhou	巩义市 Gongyi City (4), 荥阳市 Xingyang City (2), 新密市 Xinmi City (1)
	洛阳 Luoyang	新安县 Xin’an County (1)
2022	安阳 Anyang	林州市 Linzhou City (6), 龙安区 Long’an District (1)
	郑州 Zhengzhou	巩义市 Gongyi City (6), 登封市 Dengfeng City (3), 新密市 Xinmi City (1), 上街区 Shangjie District (1)
	洛阳 Luoyang	新安县 Xin’an County (2), 偃师区 Yanshi District (1)
	鹤壁 Hebi	淇滨区 Qibin District (1)
	三门峡 Sanmenxia	灵宝市 Lingbao City (1)

河南省内脏利什曼病流行病学特征和时空聚类分析

Epidemiological characteristics and spatio-temporal clustering of visceral leishmaniasis in Henan Province

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