石家庄市内脏利什曼病复现流行病学调查

doi:10.12140/j.issn.1000-7423.2023.02.020

摘要/Abstract

摘要：

从国家传染病报告信息管理系统中收集2019—2021年石家庄市报告的内脏利什曼病病例个案调查资料，采集病例所在村全部犬只的血样，同时采集报告病例家人以及以病例住处为中心、半径100 m以内邻居的静脉血样，用rk39免疫层析试纸检测血清抗利什曼原虫抗体。于2019—2021年5—9月，在病例所在庭院利用灯诱法捕获白蛉。2019—2021年，石家庄市共报告内脏利什曼病病例8例（2019年1例，2021年7例），井陉县6例，藁城区和鹿泉区各1例。男性4例，女性4例。年龄最小的1岁，最大的71岁；≤ 2岁2例，30~49岁1例，≥ 50岁5例；幼儿2例，农民5例，干部1例。7例为本地感染病例，1例为外省（山西省）输入病例。共检测犬400只，利什曼原虫抗体阳性率为11.0%（44/400）。井陉县6个村犬抗利什曼原虫抗体阳性率为6.4%~8/20（χ² = 14.76，P < 0.05），鹿泉区石井村和藁城区西辛庄村犬抗利什曼原虫抗体阳性率为1.2%（2/172）和0（0/31）；井陉县与鹿泉区和藁城区犬抗利什曼原虫抗体阳性率差异有统计学意义（χ² = 32.55、8.10，P < 0.05）。井陉县和藁城区分别采集重点人员血样309份和4份，抗利什曼原虫抗体均为阴性；鹿泉区采集重点人员血118份，利什曼原虫抗体阳性1份，阳性率为0.9%（1/118）。井陉县捕获到中华白蛉4只，鹿泉区、藁城区均未捕获到白蛉。井陉县内脏利什曼病传播风险较高，需积极采取防控措施防止疫情的进一步扩散。

关键词: 内脏利什曼病, 复现, 流行病学调查分析, 石家庄市

Abstract:

Case investigation data of visceral leishmaniasis reported in Shijiazhuang City from 2019 to 2021 was collected from the national infectious disease reporting and information management system. Blood samples were collected from all dogs in the villages where the patients reside. Meantime, venous blood samples were collected from the patient’s family members and neighbours within an area of 100 meters radius centered on the patient’s residence. The rk39 immunochromatographic test strip was used to detect serum anti-Leishmania antibodies. From May to September, sandflies were captured using light traps in the courtyards where the patients reside. A total of 8 visceral leishmaniasis cases were reported in Shijiazhuang City from 2019 to 2021 (1 case in 2019, 7 cases in 2021), 6 cases in Jingxing County, 1 case in Gaocheng District and 1 case in Luquan District respectively. There were 4 males and 4 females. Their age ranged from 1 year old to 71 years old, among which there was 2 cases aged ≤ 2 years, 1 case aged 30-49 years, 5 cases aged ≥ 50 years. There were 2 young children, 5 farmers and 1 cadre. Seven cases were infected in local counties and 1 case was imported from another province (Shanxi Province). A total of 400 dogs were tested, and the positive rate of anti-Leishmania antibody was 11.0% (44/400). The positive rates of anti-Leishmania antibody in dogs from 6 villages of Jingxing County ranged from 6.4% to 8/20 (χ² = 14.76, P < 0.05), and were 1.2% (2/172) and 0 (0/31) in dogs from Shijing Village of Luquan District and Xixinzhuang Village of Gaocheng District, respectively, with statistically significant differences between Jingxing County and Luquan District or Gaocheng District (χ² = 32.55, 8.10; P < 0.05). The 309 and 4 blood samples collected from the key personnel in Jingxing County and Gaocheng District respectively were negative for anti-Leishmania antibody, 118 blood samples collected from key personnel in Luquan District, among which 1 blood sample was positive, and the positive rate is 0.9% (1/118). Four Phlebotomus chinensis were captured in Jingxing County, while no sandflies was captured in Luquan District and Gaocheng District. There was a high risk of the spread of visceral leishmaniasis in Jingxing County. Active prevention and control measures were needed to prevent further spread.

Key words: Visceral leishmania, Recurrence, Epidemiological investigation and analsis, Shijiazhuang City

中图分类号:

R531.6

郭占景, 张世勇, 刘立. 石家庄市内脏利什曼病复现流行病学调查[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 241-244.

GUO Zhanjing, ZHANG Shiyong, LIU Li. Epidemiological investigation on the recurrence of visceral leishmaniasis in Shijiazhuang City[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(2): 241-244.

图/表 1

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