免疫调节蛋白B7家族在日本血吸虫感染免疫调节中的研究进展

doi:10.12140/j.issn.1000-7423.2022.06.013

摘要/Abstract

摘要：

日本血吸虫病是严重危害人们健康的人兽共患寄生虫病之一。血吸虫感染机体后，在早期以Th1细胞分泌干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α），CD8⁺ T细胞发挥细胞免疫为主，在慢性期Th2细胞分泌大量白细胞介素4（IL-4）、IL-13和IL-12，Th1细胞功能受到抑制，从而促使宿主产生以体液免疫为主的适应性免疫应答。免疫调节蛋白B7家族是T细胞活化的第二信号，对调节T细胞免疫应答起着至关重要的作用。该家族成员包括B7-1、B7-2、B7同源物1（B7-H1）、B7树突状细胞分子（B7-DC），B7-H2、B7-H3、B7-H4、B7-H5、B7-H6和B7-H7，对T细胞有共刺激或共抑制的作用，其中一些在血吸虫病免疫调节中发挥重要的作用。本文就B7家族成员在血吸虫感染免疫方面最新研究进展作一综述。

关键词: 日本血吸虫, B7家族, 免疫调节

Abstract:

Schistosomiasis japonica is one of the most serious zoonotic diseases in the world. After schistosome infection, Th1 cells secrete interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and CD8⁺ T cells exert cellular immunity at the early stage. Th2 cells secrete a large amount of interleukin-4 (IL-4), interleukin-13 (IL-13) and interleukin-12 (IL-12), and the function of Th1 cells is inhibited in the later stage, thus prompting the host to produce an adaptive immune response dominated by humoral immunity. The B7 family is a secondary signal of T cell activation and plays a crucial role in regulating T cell immune responses. Further studies demonstrate that B7 family contains B7-1, B7-2, B7 homologue1 (B7-H1), B7 dendritic cell molecule (B7-DC), B7-H2, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7, which have costimulatory or coinhibitory effects on T cells. Some of them play an important role in immune regulation in schistosomiasis and the research progress of the B7 family in the immune regulation during schistosome infection is summarised in this paper.

Key words: Schistosoma japonicum, B7 family, Immune regulation

中图分类号:

R532.21

陈果, 朱丹丹, 段义农. 免疫调节蛋白B7家族在日本血吸虫感染免疫调节中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(6): 774-779.

CHEN Guo, ZHU Dan-dan, DUAN Yi-nong. Research progress of immune regulation protein B7 family on immune regulation during Schistosoma japonicum infection[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2022, 40(6): 774-779.

图/表 2

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配体	别名	受体	作用
B7-1	CD80	CD28 CTLA-4	共刺激共抑制
B7-2	CD86	CD28 CTLA-4	共刺激共抑制
B7-H1	PD-L1、CD274	PD-1（CD279）	共抑制
B7-DC	PD-L2、CD273	PD-1（CD279）	共抑制
B7-H2	ICOSL、B7RP-1、 CD275	ICOS （CD278） CD28 CTLA-4	共刺激共刺激未知
B7-H3	CD276、B7RP-2	未知	共抑制
B7-H4	VTCN1、B7x、B7S1	未知	共抑制
B7-H5	VISTA、PD-1H	未知	共抑制
B7-H6	NCR3LG1	NKp30	共刺激
B7-H7	HHLA2	TMIGD2（CD28H）未知	共刺激共抑制