阿苯达唑在棘球蚴病治疗中的安全性分析

doi:10.12140/j.issn.1000-7423.2020.03.015

摘要/Abstract

摘要：

分析阿苯达唑在棘球蚴病治疗中发生各种不良反应的概率,探讨阿苯达唑在棘球蚴病治疗中的安全性,为临床安全用药提供参考。通过PubMed、EmBase、中国生物医学文献数据库、中国期刊全文数据库和万方数据库检索（检索时间为各个数据库建库开始至2019年9月）,收集阿苯达唑用于棘球蚴病治疗的文献,参照纳入与排除标准,对文献中阿苯达唑用药后发生的药物不良反应进行统计分析。共纳入26篇文献,结果显示研究地区以我国新疆为主,西藏地区对该药物的研究相对缺乏,有限的研究文献中严重不良反应发生率不高,不良反应类型常见于消化系统、皮疹、血液系统等,且多为一过性。提示目前关于阿苯达唑在棘球蚴病治疗中的不良反应发生研究有限,虽然基于现有研究提示阿苯达唑治疗有一定的安全性,但仍需更多大规模临床试验的验证和支撑。

关键词: 棘球蚴病, 阿苯达唑, 药物不良反应

Abstract:

This study aimed to investigate the probability of adverse effects of albendazole in the treatment of echinococcosis and assess the drug safety, providing reference for its safe medication in clinical practice. Literature search was performed in PubMed, EMBase, China Biology Medicine disc(CBMdisc), China National Knowledge Infrastructure(CNKI) and Wanfang Databases to obtain studies on the use of albendazole in the treatment of echinococcosis. Eligible studies were included according to the inclusion and exclusion criteria, and the reported adverse effects of albendazole were statistically analyzed. This review analyzed 26 eligible studies included, and found that the studies were mostly performed in Xinjiang, while considerably fewer performed in Tibet. According to the literature available, the occurrence rate of severe adverse effects was not high, and the adverse effects often involved digestive system, skin rash, and blood system, with transient presentation in most cases. The data indicates that the studies on the adverse side effects of albendazole is apparently limited. Although the current study results currently available suggest that albendazole is rather safe in clinical use, scale-up clinical trials remain imperative to verify this safety and address the drug safety.

Key words: Echinococcosis, Albendazol, Adverse drug reaction

中图分类号:

R532.32

刘可欣, 张伟, 金朝辉, 秦舟, 扎西群宗, 徐珽. 阿苯达唑在棘球蚴病治疗中的安全性分析[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(3): 354-359.

LIU Ke-xin, ZHANG Wei, JIN Zhao-hui, QIN Zhou, ZHAXI Qun-zong, XU Ting. Analysis on safety of albendazole in the treatment of echinococcosis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(3): 354-359.

图/表 3

表1

阿苯达唑在棘球蚴病治疗中的安全性分析文献基本情况

纳入研究	年份	地区/国家	研究类型	棘球蚴病部位	总例数	男性患者人数	女性患者人数	年龄/中位年龄
张超威^[12]	1990	N	临床观察	棘球蚴（肝、肺、腹膜、其他）	253	N	N	N
李明^[13]	1991	宁夏	对照实验	肝多房棘球蚴	80	20	60	17~71
Khuroo^[14]	1993	印度	随机对照	肝棘球蚴	20	7	13	12~64
Gil-Grande^[15]	1993	西班牙	随机对照	肝棘球蚴	37	22	15	N
李富荣^[16]	1996	兰州	临床观察	棘球蚴（肝、肺、腹膜、其他）	102	54	48	8~77
Franchi^[17]	1999	意大利	随机对照	肝棘球蚴	323	N	N	N
张贺玲^[18]	2000	新疆	临床观察	细粒棘球蚴	61	N	N	6~73
柴君杰^[19]	2001	新疆	临床观察	肝细粒棘球蚴	212	114	98	4~82
柯山^[20]	2002	新疆	对照实验	棘球蚴	53	27	26	N
亚德卡尔^[21]	2002	新疆	临床观察	肝细粒棘球蚴	71	37	34	7~70
李海涛^[22]	2004	新疆	临床观察	棘球蚴	66	35	31	8~76
Chai^[23]	2004	新疆	对照实验	肝棘球蚴	264	138	126	4~82
Bildik^[24]	2007	土耳其	随机对照	肝棘球蚴	63	N	N	N
李海涛^[25]	2010	新疆	临床观察	肝多房棘球蚴	26	10	16	14~67
朱兵^[26]	2010	新疆	临床观察	肝棘球蚴	24	15	9	15~60
Salinas^[27]	2011	秘鲁	回顾性	肝棘球蚴	27	7	20	51 ± 14
Shams^[28]	2011	印度	随机对照	肝棘球蚴	36	20	16	37 ± 12
古丽拜尔^[29]	2012	新疆	临床观察	肝细粒棘球蚴	116	54	52	N
王立英^[30]	2014	青海	临床观察	棘球蚴	160	70	110	6-16
Karabulut^[31]	2014	土耳其	回顾性	肝棘球蚴	101	38	62	47 ± 16
陈辉^[32]	2015	西藏	回顾性	脑棘球蚴 + 脑囊虫	22	15	7	26~58
Moroni^[33]	2016	美国	回顾性	棘球蚴	28	12	16	9 ± 4
Saidi^[34]	2018	伊朗	回顾性	肝棘球蚴	127	N	N	N
Fattahi^[35]	2018	伊朗	回顾性	多房棘球蚴	119	44	75	38
陈文君^[36]	2019	青海	临床观察	脑多房棘球蚴	18	10	8	21~59
Shankar^[37]	2019	印度	回顾性	棘球蚴（肝、肺）	22	15	7	13

表1

表2

表3

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