Ⅰ型干扰素在原虫感染中的作用

中国寄生虫学与寄生虫病杂志 ›› 2018, Vol. 36 ›› Issue (4): 399-404.

Ⅰ型干扰素在原虫感染中的作用

马远林¹, 吕芳丽^2,^*()

1中山大学中山医学院临床医学系,广州 510080
2中山大学中山医学院寄生虫学教研室,热带病防治研究教育部重点实验室（中山大学）,广东省媒介生物防控工程技术研究中心,广州 510080

收稿日期:2017-10-18 出版日期:2018-08-30 发布日期:2018-09-06
通讯作者: 吕芳丽
基金资助:
国家自然科学基金（No. 81471973）;中华医学会医学教育分会和中国高等教育学会医学教育专业委员会2016 年医学教育研究立项课题（No. 2016B-KY013）;中山大学本科教学改革研究项目（2018年）

The role of type Ⅰ interferon in protozoan infections

Yuan-lin MA¹, Fang-li LYU^2,^*()

1 Zhongshan School of Medicine, Sun Yat-sen University,Guangzhou 510080, China
2 Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University,Guangzhou 510080, China
3 Key Laboratory of Tropical Disease Control of Ministry of Education,Sun Yat-sen University, Guangzhou 510080, China
4 Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou 510080, China

Received:2017-10-18 Online:2018-08-30 Published:2018-09-06
Contact: Fang-li LYU
Supported by:
Supported by the National Natural Science Foundation of China (No. 81471973), the 2016 Medical Education Research Project of Chinese Medical Association Medical Education Branch and China Higher Education Society of Medical Education Professional Committee(No. 2016B-KY013), and the Education and Teaching Reform Project of Sun Yat-sen University, China(2016)

摘要/Abstract

摘要：

疟原虫、刚地弓形虫、利什曼原虫和锥虫均是严重威胁人类健康的原虫。目前已有较多研究显示,Ⅱ型干扰素（IFN-Ⅱ）在宿主抗寄生虫感染中发挥着重要的作用,但Ⅰ型干扰素（IFN-Ⅰ）在宿主抗寄生虫感染中的作用还知之甚少。原虫诱导的IFN-Ⅰ应答可因所感染的寄生虫虫种/虫株、虫荷、虫体的发育阶段或宿主的遗传背景等不同而异。IFN-Ⅰ与IFN-Ⅱ在原虫感染过程中存在相互作用。本文综述了原虫感染过程中IFN-Ⅰ的作用及其调节机制的研究进展。

关键词: Ⅰ型干扰素, 疟原虫, 刚地弓形虫, 利什曼原虫, 锥虫

Abstract:

Plasmodium spp., Toxoplasma gondii, Leishmania spp., and Trypanosoma spp. are protozoa that pose a serious health threat to humans. There has been accumulating evidence for an important role of type Ⅱ interferon (IFN-Ⅱ) against parasite infection. However, little is known on the role of IFN-Ⅰ in host defense against parasites. The IFN-Ⅰ responses induced by protozoal infection may vary according to the parasite species/strain, parasite burder, parasite develpmental stage, and the host genetic background. In addition, there are interactions between IFN-Ⅰ and IFN-Ⅱ during protozoan infection. This review summarizes recent findings on the role of IFN-Ⅰ and its regulatory mechanisms during protozoan infection.

Key words: TypeⅠinterferon, Plasmodium spp., Toxoplasma gondii, Leishmania spp., Trypanosoma spp.

中图分类号:

R531

马远林, 吕芳丽. Ⅰ型干扰素在原虫感染中的作用[J]. 中国寄生虫学与寄生虫病杂志, 2018, 36(4): 399-404.

Yuan-lin MA, Fang-li LYU. The role of type Ⅰ interferon in protozoan infections[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2018, 36(4): 399-404.

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