利什曼病疫苗的研究现状

摘要/Abstract

摘要：

利什曼病是由利什曼原虫引起的一种人兽共患寄生虫病,分布于全球90多个国家,每年新发利什曼病患者130多万,有2万~3万例死亡,给全球尤其是发展中国家带来沉重的社会经济及医疗负担。目前针对利什曼病的防治措施主要为控制传染源和药物治疗,但均无法消除利什曼病。疫苗接种是行之有效的并具社会经济效益的控制利什曼病的防治手段。因此,利什曼病疫苗的研发具有十分重要的现实意义。本文重点就利什曼原虫致病机制及各类利什曼病疫苗的研究现状进行综述。

关键词: 利什曼原虫, 利什曼病, 疫苗

Abstract:

Leishmaniasis is a zoonotic disease caused by Leishmania parasites. Currently, leishmaniasis has affected 12 million people in over 90 countries, with 1.3 million reported cases each year and 20-30 thousand deaths. The disease causes a large social and economic burden particularly in developing countries. Current strategies for leishmaniasis control include controlling the source of infection and drug treatment, both of which, however, cannot eliminate the disease. Effective vaccination would be an ideal approach to control leishmaniasis. Here, we review the pathogenic mechanism of Leishmania, the existing vaccines for veterinary use, and human vaccine development efforts against the disease.

Key words: Leishmania, Leishmaniasis, Vaccine

中图分类号:

R382.22

蔡雅霜, 张志刚, 王鑫, 赵勤俭. 利什曼病疫苗的研究现状[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(5): 499-503.

Ya-shuang CAI, Zhi-gang ZHANG, Xin WANG, Qin-jian ZHAO. Current status of vaccine development against leishmaniasis[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2017, 35(5): 499-503.

图/表 1

参考文献 32

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候选疫苗	政府临床实验编号	临床阶段	针对病症	药物联用
Alum-ALM + BCG	NCT00429715	Ⅱ期	皮肤利什曼病	-
Alum-ALM + BCG	NCT00429780	Ⅱ期/Ⅲ期
Leish-111F + MPL-SE	NCT00111553	Ⅰ期	皮肤利什曼病	-
	NCT00121849	Ⅰ期
	NCT00121862	Ⅱ期
	NCT00111514	Ⅰ期	黏膜利什曼病
	NCT00486382	Ⅰ期	内脏利什曼病/ 黑热病后皮肤利什曼病
LEISH-F2 + MPL-SE	NCT01011309	Ⅱ期	皮肤利什曼病	葡萄糖酸锑钠
LEISH-F2 + MPL-SE	NCT00982774	Ⅰ期	黑热病后皮肤利什曼病	-
LEISH-F3 + GLA-SE	NCT01484548	Ⅰ期	内脏利什曼病	-
LEISH-F3 + GLA-SE/LEISH- F3 + MPL-SE	NCT01751048	Ⅰ期	内脏利什曼病	-
LEISH-F3 + SLA-SE/LEISH- F3 + GLA-SE	NCT02071758	Ⅰ期	内脏利什曼病	-
ChAd63-KH	NCT02894008	Ⅱ期	黑热病后皮肤利什曼病	-