中国寄生虫学与寄生虫病杂志 ›› 2010, Vol. 28 ›› Issue (5): 12-381.

• 综述 • 上一篇    下一篇

Toll样受体在蠕虫感染中的作用

鱼艳荣1 *,齐永芬1,2   

  1. 北京大学基础医学院 1 寄生虫学教研室;2 生物活性小分子研究室,北京100191
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-30 发布日期:2010-11-09
  • 通讯作者: 鱼艳荣

Effect of toll-like receptors on helminth infection

YU Yan-rong 1 *,QI Yong-fen1,2   

  1. 1 Department of Medical Parasitology,School of Basic Medical Sciences,Peking University,Beijing 100191,China;2 Laboratory of Bioactive Molecule,School of Basic Medical Sciences,Peking University,Beijing 100191,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-10-30 Published:2010-11-09
  • Contact: YU Yan-rong

摘要: Toll样受体作为一类模式识别受体在免疫应答和炎性反应中发挥着重要作用。在寄生蠕虫感染中,Toll样受体同样发挥着重要作用。蠕虫可通过多种途径调节Toll样受体的表达和功能,从而调节宿主的免疫反应,影响疾病的发生发展,改善机体的免疫微环境。本文综述了Toll样受体的生物学特征,以及在蠕虫感染中对免疫应答调节作用的研究现状。

关键词: Toll样受体, 寄生虫, 蠕虫, 免疫调节

Abstract:

Toll-like receptors(TLRs) as a family of pattern-recognition receptors are vital for immune and inflammatory responses, and also play an important role in helminth infection. By regulating TLRs expression and function, helminth can alter host immune response, interfere with disease progression, and change the immune microenvironment of host. This review summarizes the biological characteristics of TLRs and recent advances of TLRs in immune modulation on helminth infection.

Key words: Toll-like receptor, Parasite, Helminth, Immune modulation