中国寄生虫学与寄生虫病杂志 ›› 2009, Vol. 27 ›› Issue (6): 15-530.

• 综述 • 上一篇    下一篇

鸡卵黄免疫球蛋白在医学领域中的应用

蔡玉春,陈家旭*   

  1. 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海 200025
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-12-30 发布日期:2009-12-30

Chicken Egg Yolk Immunoglobulin and its Application in Medicine

CAI Yu-chun,CHEN Jia-xu*   

  1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention,Key Laboratory of Parasite and Vector Biology, Ministry of Health,WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-12-30 Published:2009-12-30

摘要: 卵黄免疫球蛋白(egg yolk immunoglobulin,IgY)是鸟类、两栖类和爬行类动物的主要免疫球蛋白。IgY稳定性好,具有不激活补体系统、不与类风湿因子和蛋白A、G结合等免疫学特性,且产量高、易提取纯化。该蛋白已广泛应用于兽医学、功能食品和生物制品等方面,且在疾病预防控制和治疗方面开发潜力广阔。本文就从IgY在生物学特性、提取、纯化,以及其在免疫诊断和免疫治疗方面的应用作一综述。

关键词: 卵黄免疫球蛋白, 免疫, 制备, 诊断, 治疗

Abstract: Egg yolk immunoglobulin(IgY)is a major immunoglobulin from birds, amphibians and reptiles. IgY does not activate mammalian complement system, and does not bind to mammalian rheumatoid factors, protein A or G. In addition, it has a high yield, and is easy to extract and purify. With these advantages,IgY has been widely used in veterinary science, functional food and bio-products, and proved potential application for disease control and treatment. This paper reviews biological characteristics of IgY, its extraction, purification, and application in immunodiagnosis and treatment.

Key words: Egg yolk immunoglobulin(IgY), Immunization, Preparation, Diagnosis, Treatment