代谢组学在医学蠕虫研究中的应用

doi:10.12140/j.issn.1000-7423.2021.05.020

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (5): 703-709.doi: 10.12140/j.issn.1000-7423.2021.05.020

代谢组学在医学蠕虫研究中的应用

胡玥¹(), 吕志跃¹^,²^,³^,^*()

1 中山大学中山医学院寄生虫学教研室,广州 510080
2 海南医学院热带转化医学教育部重点实验室,海口 571199
3 海南医学院热带病防治国家卫生健康委员会重点实验室,海口 571199

收稿日期:2021-03-28 修回日期:2021-04-25 出版日期:2021-10-30 发布日期:2021-11-10
通讯作者: 吕志跃
作者简介:胡玥（1993-）,女,博士研究生,从事病原生物学研究。E-mail： huyue43@mail2.sysu.edu.cn
基金资助:
国家自然科学基金(82072303);国家寄生虫资源库(NPRC-2019-194-30);海南省重点研发计划项目(ZDYF2020120);海南省院士创新平台科研专项项目(YSCX202110);海南省重大科技计划项目(ZDKJ202003)

Application of metabolomics in research of medical helminths

HU Yue¹(), LV Zhi-yue¹^,²^,³^,^*()

1 Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
2 Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199, China
3 National Health Council Key Laboratory of Control of Tropical Diseases, Hainan Medical University, Haikou 571199, China

Received:2021-03-28 Revised:2021-04-25 Online:2021-10-30 Published:2021-11-10
Contact: LV Zhi-yue
Supported by:
National Natural Science Foundation of China(82072303);National Parasitic Resources Center of China(NPRC-2019-194-30);Key Research and Development Program of Hainan Province(ZDYF2020120);Specific Grant of Academician Innovation Platform of Hainan Province(YSCX202110);Major Science and Technology Program of Hainan Province(ZDKJ202003)

摘要/Abstract

摘要：

代谢组学是继基因组学、转录组学和蛋白质组学之后迅速发展起来的一种新兴组学,由于其独特的优势,在疾病早期诊断、药物靶点发现及动植物代谢研究等各个领域中均有应用。如今在寄生虫研究领域中的应用也逐渐增多,主要集中于寄生虫宿主的代谢研究、寄生虫病诊断生物标志物的筛选以及揭示寄生虫病治疗药物的作用机制等方面,为探究寄生虫与宿主相互作用、寄生虫病诊疗等方面提供了新的思路。本文通过对代谢组学及其研究方法、代谢组学在医学蠕虫研究中的应用进展进行综述,以期为其在寄生虫研究领域的广泛应用提供参考。

关键词: 医学蠕虫, 代谢组学, 应用进展

Abstract:

Metabolomics is a new type of omics that rapidly developed after genomics, transcriptomics and proteomics. Because of its unique advantages, metabolomics has been applied in early diagnosis of diseases, discovery of drug targets, and for understanding animal and plant metabolisms. Metabolomics has been increasingly using in studies of paras ites, focusing on parasites’ metabolism, screening diagnostic biomarkers and revealing mechanism of drug actions, to provide new ideas for exploring parasite-host interaction, and for further understanding of diagnosis and treatment of parasitic diseases. In this review, we summarize metabolomics associated research methodologies, and advances of their applications in studies of medical helminths, to provide reference for wider application of metabolomics in parasitology research.

Key words: Medical helminths, Metabolomics, Current applications

中图分类号:

R383

胡玥, 吕志跃. 代谢组学在医学蠕虫研究中的应用[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(5): 703-709.

HU Yue, LV Zhi-yue. Application of metabolomics in research of medical helminths[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(5): 703-709.

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代谢组学在医学蠕虫研究中的应用

Application of metabolomics in research of medical helminths

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