弓形虫感染与精神分裂症相关性的研究进展

doi:10.12140/j.issn.1000-7423.2019.01.019

摘要/Abstract

摘要：

弓形虫感染是艾滋病患者的最常见的机会性感染之一。弓形虫除可导致严重感染外,近年来发现弓形虫感染可影响精神分裂症的发病和进程,两者间存在一些内在联系。许多研究结果显示,弓形虫感染可能通过损害神经系统、影响神经递质和免疫系统等多种途径影响精神分裂症的发病和进程,但具体机制尚不明确。研究两者的内在联系,有助于了解精神分裂症的发病机制与影响因素,为精神分裂症的防治研究提供新的方向。本文对弓形虫感染与精神分裂症相关性的研究进展进行综述。

关键词: 弓形虫, 精神分裂症, 艾滋病, 机会性感染

Abstract:

Toxoplasma gondii infection is one of the most common opportunistic infections in acquired immune deficiency syndrome patients. In addition to the pathogenesis directly caused by the infection, it has been found that T. gondii infection is related to the onset and progression of schizophrenia in recent years. Many studies have shown that Toxoplasma infection may affect the pathogenesis and progression of schizophrenia by damaging the nervous system, affecting neurotransmitters and the immune system. However, the specific mechanism underlying this correlation is still unclear. Understanding the intrinsic relationship between Toxoplasma infection and schizophrenia will help to interpret the pathogenesis and influencing factors of schizophrenia and provide a new direction for the prevention and treatment of schizophrenia. This article aims to review the progress in research on the correlation between T. gondii infection and schizophrenia.

Key words: Toxoplasma gondii, Schizophrenia, Acquired immune deficiency syndrome, Opportunistic infection

中图分类号:

R382.5

欧阳净, 陈耀凯. 弓形虫感染与精神分裂症相关性的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(1): 102-106.

Jing OUYANG, Yao-kai CHEN. Progress in research on the correlation between Toxoplasma gondii infection and schizophrenia[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2019, 37(1): 102-106.

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