CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2022 , Vol. 40 >Issue 4: 511 - 515

DOI: https://doi.org/10.12140/j.issn.1000-7423.2022.04.015

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Research progress on clinical trials of schistosomiasis vaccine candidates

  • CHEN Bing ,
  • ZHANG Guo-li ,
  • ZHANG Gao-hong
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  • 1. School of Medicine, Kunming University, Kunming 650214, China
    2. School of Pharmaceutical Sciences, Kunming Medical University, Kunming 650500, China
*E-mail: zghwbj@163.com

Received date: 2021-12-27

  Revised date: 2022-01-20

  Online published: 2022-09-07

Supported by

Scientific Research Fund Project of Yunnan Education Department(2021J0711);National Natural Science Foundation of China(81860486)

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Abstract

Schistosomiasis is a wide-spread parasitic zoonosis caused by Schistosoma, which seriously harms human health and affects socioeconomic development worldwide. Schistosomiasis vaccines have attracted much attention as they will contribute not only to reducing the over-reliance on praziquantel for the treatment of this disease but also to achieving the goal of disease control and elimination. There have been no schistosomiasis vaccines available until now; however, four schistosomiasis vaccine candidates, glutathione S-transferase, fatty acid binding protein, tetraspanin-2 and calpain, have entered human clinical trials. This paper reviewed the clinical research progress and challenges of the four schistosomiasis vaccine candidates to provide insights into developing vaccines for schistosomiasis and other helminthiases in China.

Key words： Schistosomiasis; Vaccine; Antigen; Human clinical trial

Cite this article

CHEN Bing , ZHANG Guo-li , ZHANG Gao-hong . Research progress on clinical trials of schistosomiasis vaccine candidates[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022 , 40(4) : 511 -515 . DOI: 10.12140/j.issn.1000-7423.2022.04.015

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