CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research advances on exosome and its functions to parasitic helminths
Received date: 2021-09-26
Revised date: 2021-11-15
Online published: 2022-07-06
Supported by
National Key Research and Development Program of China(2021YFC2300800);National Key Research and Development Program of China(2021YFC2300801);National Key Research and Development Program of China(2020YFC1200100);Guangdong Natural Science Foundation(2022A1515012560);Guangdong Natural Science Foundation(2019A1515010583)
Exosomes are bilayer vesicular bodies secreted by a variety of variable cells, containing many important bioactive substances, including proteins, lipids and nucleic acids, which are involved in important physiological processes such as cell-to-cell communication and immune regulation. Exosomes from parasites play a critical role in parasite-host interaction, which can regulate the host immune response through various mechanisms and manipulate host cell function. It is an important medium for the interaction between parasite and parasite, as well as between parasite and host. This review has summarized the recent advances on the pathogenicity, immune regulation and immune evasion of exosomes in trematodes, nematodes and cestodes to help the study of exosomes in parasitic helminths.
Key words： Helminth; Exosome; Parasite-host interaction; Immune regulation
PAN Xiao-wen , WU Yin-juan , HE Qing , YIN Ying-xuan , LI Xue-rong . Research advances on exosome and its functions to parasitic helminths[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022 , 40(3) : 390 -395 . DOI: 10.12140/j.issn.1000-7423.2022.03.017
| [1] | Doyle LM,, Wang MZ. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis[J]. Cells, 2019, 8(7): E727. |
| [2] | Yáñez-Mó M,, Siljander PR,, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions[J]. J Extracell Vesicles, 2015, 4(1): 27066. |
| [3] | Kalluri R,, LeBleu VS. The biology, function, and biomedical applications of exosomes[J]. Science, 2020, 367(6478): eaau6977. |
| [4] | Wu ZY,, Wang LL,, Li JY, et al. Extracellular vesicle-mediated communication within host-parasite interactions[J]. Front Immunol, 2018, 9: 3066. |
| [5] | Kourembanas S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy[J]. Annu Rev Physiol, 2015, 77: 13-27. |
| [6] | Tkach M,, Théry C. Communication by extracellular vesicles: where we are and where we need to go[J]. Cell, 2016, 164(6): 1226-1232. |
| [7] | Colombo M,, Raposo G,, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles[J]. Annu Rev Cell Dev Biol, 2014, 30: 255-289. |
| [8] | Cheng WJ,, Jiang H,, Dong HF, et al. Advances in researches of exosomes and other extracellular vesicles in parasites and parasitic diseases[J]. Chin J Schisto Control, 2019, 31(5): 555-559. (in Chinese) |
| [8] | ( 程文君,, 蒋洪,, 董惠芬, 等. 外泌体及其他细胞外囊泡在寄生虫与寄生虫病研究中的进展[J]. 中国血吸虫病防治杂志, 2019, 31(5): 555-559.) |
| [9] | Sotillo J,, Robinson MW,, Kimber MJ, et al. The protein and microRNA cargo of extracellular vesicles from parasitic helminths: current status and research priorities[J]. Int J Parasitol, 2020, 50(9): 635-645. |
| [10] | Nawaz M,, Malik MI,, Hameed M, et al. Research progress on the composition and function of parasite-derived exosomes[J]. Acta Trop, 2019, 196: 30-36. |
| [11] | Raposo G,, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends[J]. J Cell Biol, 2013, 200(4): 373-383. |
| [12] | Zaborowski MP,, Balaj L,, Breakefield XO, et al. Extracellular vesicles: composition, biological relevance, and methods of study[J]. Bioscience, 2015, 65(8): 783-797. |
| [13] | Valadi H,, Ekström K,, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J]. Nat Cell Biol, 2007, 9(6): 654-659. |
| [14] | Ofir-Birin Y,, Regev-Rudzki N. Extracellular vesicles in parasite survival[J]. Science, 2019, 363(6429): 817-818. |
| [15] | Huang L,, Ye CL,, Sheng Y, et al. Advances in research on parasite exosomal miRNA[J]. J Pathog Biol, 2019, 14(9): 1115-1118. (in Chinese) |
| [15] | ( 黄琳,, 叶昌林,, 生燕, 等. 外泌体miRNA在寄生虫中的进展[J]. 中国病原生物学杂志, 2019, 14(9): 1115-1118.) |
| [16] | Mehmood K,, Zhang H,, Sabir AJ, et al. A review on epidemiology, global prevalence and economical losses of fasciolosis in ruminants[J]. Microb Pathog, 2017, 109: 253-262. |
| [17] | Davis CN,, Winters A,, Milic I, et al. Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica[J]. Sci Rep, 2020, 10(1): 13445. |
| [18] | Marcilla A,, Trelis M,, Cortés A, et al. Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells[J]. PLoS One, 2012, 7(9): e45974. |
| [19] | Cwiklinski K,, de la Torre-Escudero E,, Trelis M, et al. The extracellular vesicles of the helminth pathogen, Fasciola hepatica: biogenesis pathways and cargo molecules involved in parasite pathogenesis[J]. Mol Cell Proteomics, 2015, 14(12): 3258-3273. |
| [20] | Fromm B,, Ovchinnikov V,, Høye E, et al. On the presence and immunoregulatory functions of extracellular microRNAs in the trematode Fasciola hepatica[J]. Parasite Immunol, 2017, 39(2): e12399. |
| [21] | Roig J,, Saiz ML,, Galiano A, et al. Extracellular vesicles from the helminth Fasciola hepatica prevent DSS-induced acute ulcerative colitis in a T-lymphocyte independent mode[J]. Front Microbiol, 2018, 9: 1036. |
| [22] | Brindley PJ,, da Costa JM,, Sripa B. Why does infection with some helminths cause cancer?[J]. Trends Cancer, 2015, 1(3): 174-182. |
| [23] | Suwannatrai A,, Saichua P,, Haswell M. Epidemiology of Opisthorchis viverrini infection[J]. Adv Parasitol, 2018, 101: 41-67. |
| [24] | Chaiyadet S,, Sotillo J,, Smout M, et al. Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype[J]. J Infect Dis, 2015, 212(10): 1636-1645. |
| [25] | Suttiprapa S,, Sotillo J,, Smout M, et al. Opisthorchis viverrini proteome and host-parasite interactions[J]. Adv Parasitol, 2018, 102: 45-72. |
| [26] | Arunsan P,, Chaidee A,, Cochran CJ, et al. Liver fluke granulin promotes extracellular vesicle-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma[J]. Neoplasia, 2020, 22(5): 203-216. |
| [27] | Sun CS,, Hu W,, Wang TP. Advances in research on schistosome-host interactions mediated by extracellular vesicles[J]. Chin J Parasitol Parasit Dis, 2020, 38(3): 378-382. (in Chinese) |
| [27] | ( 孙成松,, 胡薇,, 汪天平. 胞外囊泡介导血吸虫与宿主相互作用的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(3): 378-382.) |
| [28] | Wang LF,, Li ZT,, Shen J, et al. Exosome-like vesicles derived by Schistosoma japonicum adult worms mediates M1 type immune-activity of macrophage[J]. Parasitol Res, 2015, 114(5): 1865-1873. |
| [29] | Sotillo J,, Pearson M,, Potriquet J, et al. Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates[J]. Int J Parasitol, 2016, 46(1): 1-5. |
| [30] | Samoil V,, Dagenais M,, Ganapathy V, et al. Vesicle-based secretion in schistosomes: analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni[J]. Sci Rep, 2018, 8(1): 3286. |
| [31] | Kifle DW,, Pearson MS,, Becker L, et al. Proteomic analysis of two populations of Schistosoma mansoni-derived extracellular vesicles: 15k pellet and 120k pellet vesicles[J]. Mol Biochem Parasitol, 2020, 236: 111264. |
| [32] | Lin Y,, Zhu SL,, Hu C, et al. Cross-species suppression of hepatoma cell growth and migration by a Schistosoma japonicum microRNA[J]. Mol Ther Nucleic Acids, 2019, 18: 400-412. |
| [33] | Giri BR,, Cheng GF. Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection[J]. Int J Parasitol, 2019, 49(13/14): 993-997. |
| [34] | Liu JT,, Zhu LH,, Wang JB, et al. Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism[J]. PLoS Pathog, 2019, 15(6): e1007817. |
| [35] | Wang LF,, Liao Y,, Yang RB, et al. Sja-miR-71a in schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D[J]. J Extracell Vesicles, 2020, 9(1): 1785738. |
| [36] | Coakley G,, Wright MD,, Borger JG. Schistosoma mansoni-derived lipids in extracellular vesicles: potential agonists for eosinophillic tissue repair[J]. Front Immunol, 2019, 10: 1010. |
| [37] | Avni D,, Avni O. Extracellular vesicles: schistosomal long-range precise weapon to manipulate the immune response[J]. Front Cell Infect Microbiol, 2021, 11: 649480. |
| [38] | Wang W,, Zhou XJ,, Cui F, et al. Proteomic analysis on exosomes derived from patients’ sera infected with Echinococcus granulosus[J]. Korean J Parasitol, 2019, 57(5): 489-497. |
| [39] | Nicolao MC,, Rodriguez Rodrigues C,, Cumino AC. Extracellular vesicles from Echinococcus granulosus larval stage: isolation, characterization and uptake by dendritic cells[J]. PLoS Negl Trop Dis, 2019, 13(1): e0007032. |
| [40] | Li ZJ,, Liang JP. Study on the influence of protoscoleces exosome on the activation and cytokine secretion of dendritic cells[J]. Chin J Prev Vet Med, 2020, 42(1): 70-74. (in Chinese) |
| [40] | ( 李宗吉,, 梁锦屏. 原头蚴外泌体对树突状细胞活化和细胞因子分泌的影响[J]. 中国预防兽医学报, 2020, 42(1): 70-74.) |
| [41] | Yang J,, Wu JE,, Fu Y, et al. Identification of different extracellular vesicles in the hydatid fluid of Echinococcus granulosus and immunomodulatory effects of 110 K EVs on sheep PBMCs[J]. Front Immunol, 2021, 12: 602717. |
| [42] | Zhang XF,, Gong WC,, Cao SK, et al. Comprehensive analysis of non-coding RNA profiles of exosome-like vesicles from the protoscoleces and hydatid cyst fluid of Echinococcus granulosus[J]. Front Cell Infect Microbiol, 2020, 10: 316. |
| [43] | Zheng YD,, Guo XL,, Su M, et al. Regulatory effects of Echinococcus multilocularis extracellular vesicles on RAW264.7 macrophages[J]. Vet Parasitol, 2017, 235: 29-36. |
| [44] | Ding JT,, He GT,, Wu JE, et al. miRNA-seq of Echinococcus multilocularis extracellular vesicles and immunomodulatory effects of miR-4989[J]. Front Microbiol, 2019, 10: 2707. |
| [45] | Buck AH,, Coakley G,, Simbari F, et al. Erratum: exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity[J]. Nat Commun, 2015, 6: 8772. |
| [46] | Coakley G,, McCaskill JL,, Borger JG, et al. Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity[J]. Cell Rep, 2017, 19(8): 1545-1557. |
| [47] | Kosanović M,, Cvetković J,, Gruden-Movsesijan A, et al. Trichinella spiralis muscle larvae release extracellular vesicles with immunomodulatory properties[J]. Parasite Immunol, 2019, 41(10): e12665. |
| [48] | Yang Y,, Liu L,, Liu XL, et al. Extracellular vesicles derived from Trichinella spiralis muscle larvae ameliorate TNBS-induced colitis in mice[J]. Front Immunol, 2020, 11: 1174. |
| [49] | Gao X,, Yang Y,, Liu XL, et al. Extracellular vesicles derived from Trichinella spiralis prevent colitis by inhibiting M1 macrophage polarization[J]. Acta Trop, 2021, 213: 105761. |
| [50] | Cao CL,, Guo JG. Challenge and strategy of prevention and control of important parasitic diseases under the Belt and Road Initiative[J]. Chin J Schisto Control, 2018, 30(2): 111-116. (in Chinese) |
| [50] | ( 曹淳力,, 郭家钢. “一带一路”建设中重要寄生虫病防控面临的挑战与对策[J]. 中国血吸虫病防治杂志, 2018, 30(2): 111-116.) |
| [51] | Zamanian M,, Fraser LM,, Agbedanu PN, et al. Release of small RNA-containing exosome-like vesicles from the human filarial parasite Brugia malayi[J]. PLoS Negl Trop Dis, 2015, 9(9): e0004069. |
| [52] | Banerjee S,, Xie N,, Cui HC, et al. microRNA let-7c regulates macrophage polarization[J]. J Immunol, 2013, 190(12): 6542-6549. |
| [53] | Ricciardi A,, Bennuru S,, Tariq S, et al. Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway[J]. PLoS Negl Trop Dis, 2021, 15(1): e0008884. |
/
| 〈 |
|
〉 |