CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection
Received date: 2020-10-16
Revised date: 2021-01-22
Online published: 2021-08-11
Supported by
National Natural Science Foundation of China(81772224);National Natural Science Foundation of China(82072307);National Major Science and Technology Projects of China(2018ZX10713001-004)
Myeloid-derived suppressor cells (MDSCs) are a group of immature heterogeneous myeloid cells, which are the precursors of dendritic cells, macrophages, and granulocytes. These precursor cells can be recruited to microenvironments, such as lymph nodes, spleen, peripheral blood and tumor, under pathological conditions, where they are further activated. After activation, MDSCs can suppress T cell immune response through various mechanisms, which are widely involved in different stages of parasitic infection. This review summarizes the research progress on the immunosuppressive function of MDSCs in the field of parasitic infection.
Ye-ting SUN , Jian-ping CAO , Yu-juan SHEN . Research progress on immunosuppressive function of myeloid-derived suppressor cells and its role in parasitic infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021 , 39(4) : 505 -513 . DOI: 10.12140/j.issn.1000-7423.2021.04.014
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