Objective To analyze the epidemiological characteristics of malaria in Henan Province in 2019, in order to provide a basis for formulating effective strategies and measures for surveillance after malaria elimination in Henan Province. Methods Data of malaria cases in Henan Province in 2019 were collected. The epidemiological information of malaria was analyzed with the descriptive epidemiological method. Results A total of 228 cases of malaria were reported in 2019, including 176 cases (77.2%) of falciparum malaria, 12 cases of vivax malaria, 33 cases of oval malaria and 7 cases of quartan malaria; having 222 male(97.4%) and 6 female cases. The majority of the cases was aged between 30 to 59 years (82.9%, 189/228) and were migrant workers (78.9%, 180/228). All of the malaria cases were imported cases and 96.1% (219/228) of them were from Africa. The top five cities having highest reports of cases were Zhengzhou (77 cases), Luoyang (22), Puyang (20), Anyang (19) and Xuchang cities (15), which accounted for 67.1% of total cases in Henan Province. The cases were reported throughout the year, particularly higher in January and December. The average time from onset to first visit to a doctor was 1.6 d and 202 (88.6%) cases went to visit a doctor within 3 days after onset. The average time from the first visit to confirmed diagnosis was 1.7 d, and 188 (82.5%) cases were diagnosed as malaria within 3 days. All of the cases (100%) were reported within 24 h, of them, 225 cases (98.7%) were underwent epidemiological investigation within 3 days, while 213 (93.4%) epidemic sites were surveyed within 7 days. Conclusion All the cases reported from Henan Province in 2019 were imported from abroad. It is suggested that the local health sections should strengthen the surveillance of imported cases from abroad to prevent the occurrence of secondary cases.