CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Analysis on safety of albendazole in the treatment of echinococcosis
Received date: 2019-10-21
Online published: 2020-07-07
Supported by
Key Research and Development Projects for Science and Technology Department of Sichuan Province(2017FZ0104)
This study aimed to investigate the probability of adverse effects of albendazole in the treatment of echinococcosis and assess the drug safety, providing reference for its safe medication in clinical practice. Literature search was performed in PubMed, EMBase, China Biology Medicine disc(CBMdisc), China National Knowledge Infrastructure(CNKI) and Wanfang Databases to obtain studies on the use of albendazole in the treatment of echinococcosis. Eligible studies were included according to the inclusion and exclusion criteria, and the reported adverse effects of albendazole were statistically analyzed. This review analyzed 26 eligible studies included, and found that the studies were mostly performed in Xinjiang, while considerably fewer performed in Tibet. According to the literature available, the occurrence rate of severe adverse effects was not high, and the adverse effects often involved digestive system, skin rash, and blood system, with transient presentation in most cases. The data indicates that the studies on the adverse side effects of albendazole is apparently limited. Although the current study results currently available suggest that albendazole is rather safe in clinical use, scale-up clinical trials remain imperative to verify this safety and address the drug safety.
Key words： Echinococcosis; Albendazol; Adverse drug reaction
Ke-xin LIU , Wei ZHANG , Zhao-hui JIN , Zhou QIN , Qun-zong ZHAXI , Ting XU . Analysis on safety of albendazole in the treatment of echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020 , 38(3) : 354 -359 . DOI: 10.12140/j.issn.1000-7423.2020.03.015
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