CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2020 , Vol. 38 >Issue 2: 250 - 254

DOI: https://doi.org/10.12140/j.issn.1000-7423.2020.02.019

REVIEWS

Advances in the pathogenesis of cholangiocarcinoma caused by Clonorchis sinensis

  • Xiao LI ,
  • Jiang-chang WANG ,
  • Lei GUAN ,
  • Qi GU ,
  • Ji-ze DONG ,
  • Chen-yun WU ,
  • Min YAN ,
  • Zhao-jun WANG
Expand
  • 1 Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, China
    2 Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    3 School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2019-07-29

  Online published: 2020-05-11

Supported by

Supported by the Natural Science Foundation of Shanghai(19ZR1428500);the National Natural Science Foundation of China(81971486)

Fold

Abstract

Clonorchis sinensis is a food-borne parasite that can cause hepatobiliary lesions and even cholangiocarcinoma. This review summarizes recent progress in the pathogenesis of cholangiocarcinoma caused by C. sinensis, from perspectives of toxicity of worms, abnormal immune responses of hosts and co-infection with other pathogens.

Key words： Clonorchis sinensis; Cholangiocarcinoma; Excretory/secretory products; Immune factors

Cite this article

Xiao LI , Jiang-chang WANG , Lei GUAN , Qi GU , Ji-ze DONG , Chen-yun WU , Min YAN , Zhao-jun WANG . Advances in the pathogenesis of cholangiocarcinoma caused by Clonorchis sinensis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020 , 38(2) : 250 -254 . DOI: 10.12140/j.issn.1000-7423.2020.02.019

References

[1] Lee YI, Seo M, Kim SB . Infections of soil-transmitted helminth in refugees from North Korea[J]. Korean J Parasitol, 2018,56(3):291-294.
[2] Yoshida Y . Clonorchiasis--a historical review of contributions of Japanese parasitologists[J]. Parasitol Int, 2012,61(1):5-9.
[3] Qian MB, Utzinger J, Keiser J , et al. Clonorchiasis[J]. Lancet, 2016,387(10020):800-810.
[4] Lai DH, Hong XK, Su BX , et al. Current status of Clonorchis sinensis and clonorchiasis in China[J]. Trans R Soc Trop Med Hyg, 2016,110(1):21-27.
[5] Zhang XL, Dong YX, Han S , et al. Study on liver injury and model of rat infected by Clonorchis sinensis[J]. J Trop Dis Parasitol, 2011,9(2):81-83, 126. (in Chinese)
[5] ( 张晓丽, 董云霞, 韩甦 , 等. 肝吸虫感染大鼠模型的建立及肝损伤的观察[J]. 热带病与寄生虫学, 2011,9(2):81-83, 126.)
[6] Kim TS, Pak JH, Kim JB , et al. Clonorchis sinensis, an oriental liver fluke, as a human biological agent of cholangiocarcinoma: a brief review[J]. BMB Reports, 2016,49(11):590-597.
[7] Bridgewater J, Galle PR, Khan SA , et al. Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma[J]. J Hepatol, 2014,60(6):1268-1289.
[8] Razumilava N, Gores GJ . Cholangiocarcinoma[J]. Lancet, 2014,383(9935):2168-2179.
[9] Khan SA, Thomas HC, Davidson BR , et al. Cholangiocarcinoma[J]. Lancet, 2005,366(9493):1303-1314.
[10] Fang WH, Mai WQ, Gao ZW , et al. Association between cholangiocarcinoma and Clonorchis Sinensis[J]. M M I, 2019,28(1):71-72. (in Chinese)
[10] ( 方卫华, 麦威铨, 高镇伟 , 等. 胆管细胞癌与华支睾吸虫病的相关性研究[J]. 现代医用影像学, 2019,28(1):71-72.)
[11] Wang DX, Young ND, Korhonen PK , et al. Clonorchis sinensis and clonorchiasis: the relevance of exploring genetic variation[J]. Adv Parasit, 2018,100:155-208.
[12] Liu GX, Wu XP, Wang ZJ , et al. Research progress on the relationship between three kinds of liver fluke infections and cholangiocarcinoma[J]. Chin J Parasitol Parasit Dis, 2010,28(4):301-305. (in Chinese)
[12] ( 刘国兴, 吴秀萍, 王子见 , 等. 三种吸虫感染与胆管癌发病关系的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2010,28(4):301-305.)
[13] Pan Y, Rong W, Li ZH , et al. Pathological observation of liver in mice infected with Clonorchis Sinensis[J]. Med Innovat Chin, 2017,14(30):15-18. (in Chinese)
[13] ( 潘钰, 荣玮, 李致慧 , 等. 感染华支睾吸虫后小鼠肝脏的病理学观察[J]. 中国医学创新, 2017,14(30):15-18.)
[14] Liu JX, Sun YH, Sun Y . Study of the development of Clonorchis Sinensis in susceptible animals and pathological changes in the liver[J]. J Pathog Biol, 2016,11(7):649-652. (in Chinese)
[14] ( 刘继鑫, 孙艳宏, 孙艳 . 易感动物体内华支睾吸虫的发育及其肝脏病理学变化研究[J]. 中国病原生物学杂志, 2016,11(7):649-652.)
[15] Tang ZL, Huang Y, Yu XB . Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control[J]. Infect Dis Poverty, 2016,5(1):71-83.
[16] Pak JH, Kim IK, Kim SM , et al. Induction of cancer-related microRNA expression profiling using excretory-secretory products of Clonorchis sinensis[J]. Parasitol Res, 2014,113:4447-4455.
[17] Shen JQ, Yang QL, Xue Y , et al. Inducible nitric oxide synthase response and associated cytokine gene expression in the spleen of mice infected with Clonorchis sinensis[J]. Parasitol Res, 2015,114(5):1661-1670.
[18] Pak JH, Son WC, Seo SB , et al. Peroxiredoxin 6 expression is inversely correlated with nuclear factor-kappaB activation during Clonorchis sinensis infestation[J]. Free Radic Biol Med, 2016,99:273-285.
[19] Bahk YY, Pak JH . Toll-like receptor-mediated free radical generation in Clonorchis sinensis excretory-secretory product-treated cholangiocarcinoma cells[J]. Korean J Parasitol, 2016,54(5):679-684.
[20] Floyd RA, Carney JM . Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress[J]. Ann Neurol, 1992,32(S1):S22-27.
[21] Maeng S, Lee HW, Bashir Q , et al. Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection[J]. Int J Parasitol, 2016,46(3):195-204.
[22] Pak JH, Shin J, Song IS , et al. Clonorchis sinensis excretory-secretory products regulate migration and invasion in cholangiocarcinoma cells via extracellular signal-regulated kinase 1/2/nuclear factor-kappa B-dependent matrix metalloproteinase-9 expression[J]. Int J Parasitol, 2017,47(1):51-59.
[23] Pak JH, Bashir Q, Kim IK , et al. Clonorchis sinensis excretory-secretory products promote the migration and invasion of cholangiocarcinoma cells by activating the integrin β4-FAK/Src signaling pathway[J]. Mol Biochem Parasitol, 2017,214:1-9.
[24] Won J, Cho Y, Lee D , et al. Clonorchis sinensis excretory-secretory products increase malignant characteristics of cholangiocarcinoma cells in three-dimensional co-culture with biliary ductal plates[J]. PLoS Pathog, 2019,15(5):e1007818.
[25] Rojas J, Salazar J, Martinez MS , et al. Macrophage heterogeneity and plasticity: impact of macrophage biomarkers on atherosclerosis[J]. Scientifica (Cairo), 2015,2015:851252.
[26] Kim EM, Kwak YS, Yi MH , et al. Clonorchis sinensis antigens alter hepatic macrophage polarization in vitro and in vivo[J]. PLoS Negl Trop Dis, 2017,11(5):e0005614.
[27] Landskron G , De la Fuente M, Thuwajit P, et al. Chronic inflammation and cytokines in the tumor microenvironment[J]. J Immunol Res, 2014,2014:149185.
[28] Mott JL, Gores GJ . Targeting IL-6 in cholangiocarcinoma therapy[J]. Am J Gastroenterol, 2007,102(10):2171-2172.
[29] Isomoto H, Kobayashi S, Werneburg NW , et al. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells[J]. Hepatology, 2005,42(6):1329-1338.
[30] Wehbe H, Henson R, Meng F , et al. Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression[J]. Cancer Res, 2006,66(21):10517-10524.
[31] Wi HJ, Jin Y, Choi MH , et al. Predominance of IL-10 and TGF-beta production from the mouse macrophage cell line, RAW264.7, in response to crude antigens from Clonorchis sinensis[J]. Cytokine, 2012,59(2):237-244.
[32] Kong XZ, Wang S, Chen TJ , et al. Correlation between the pathogenicity of Clonorchis sinensis and macrophage polarization[J]. J Trop Med, 2018,18(4):423-427. (in Chinese)
[32] ( 孔祥展, 宛硕, 陈庭金 , 等. 华支睾吸虫致病与巨噬细胞极化的相关性[J]. 热带医学杂志, 2018,18(4):423-427.)
[33] Jin Y, Wi HJ, Choi MH , et al. Regulation of anti-inflammatory cytokines IL-10 and TGF-beta in mouse dendritic cells through treatment with Clonorchis sinensis crude antigen[J]. Exp Mol Med, 2014,46:e74.
[34] Thepmalee C, Panya A, Junking M , et al. Inhibition of IL-10 and TGF-beta receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells[J]. Hum Vaccin Immunother, 2018,14(6):1423-1431.
[35] Yamazaki S, Steinman RM . Dendritic cells as controllers of antigen-specific Foxp3 + regulatory T cells [J]. J Dermatol Sci, 2009,54(2):69-75.
[36] Yan C, Zhang BB, Hua H , et al. The dynamics of Treg/Th17 and the imbalance of Treg/Th17 in Clonorchis sinensis-infected mice[J]. PLoS One, 2015,10(11):e0143217.
[37] Qian MB, Chen YD, Zhou XN . From recognition to practice: the 140 th anniversary of the discovery of Clonorchis sinensis [J]. Chin J Parasitol Parasit Dis, 2014,32(04):247-252. (in Chinese)
[37] ( 钱门宝, 陈颖丹, 周晓农 . 从认识到实践——纪念华支睾吸虫发现 140 周年[J]. 中国寄生虫学与寄生虫病杂志, 2014,32(04):247-252.)
[38] Shi YL, Jiang ZH, Yang YC , et al. Clonorchis sinensis infection and co-infection with the hepatitis B virus are important factors associated with cholangiocarcinoma and hepatocellular carcinoma[J]. Parasitol Res, 2017,116(10):2645-2649.
[39] Li W, Dong H, Huang Y , et al. Clonorchis sinensis co-infection could affect the disease state and treatment response of HBV patients[J]. PLoS Negl Trop Dis, 2016,10(6):e0004806.
[40] Liu QN, Dong HM, Sun HC , et al. Effects of Clonorchis sinensis and HBV co-infection on hepatic stellate cell and macrophage[J]. J Trop Med, 2019,19(4):387-392. (in Chinese)
[40] ( 刘倩楠, 董慧敏, 孙恒昌 , 等. 华支睾吸虫合并HBV感染对肝星状细胞和巨噬细胞作用的体外研究[J]. 热带医学杂志, 2019,19(4):387-392.)
Options
Outlines

/

〈 〉