Abstract: 50 cases of cerebral cysticercosis cellulosae were treated with praziquantel kindly supplied by Bayer AG. Each course consisted of 120mg/kg in 4-6 days. 27 patients received 2 courses; 2 patients received 3 courses. 42 cases followed up for 1-3 years after treatment showed that most of the subcutaneous or intra-muscular cysticercous nodules disappeared or reduced in size. The neuropsychic symptoms, such as epileptic seizure, headache, nausea, vomiting and mental disturbance were markedly improved, except in few cases who turned to be aggravated. The side effects including exacerbatidn of epileptic seizure and other neuropsychic symptoms during or within a short period post therapy were found much severer than those found in subcutaneous muscular type oysticercosis treated with, the same dosage and course, probably due to the allergic reaction caused by the damaged cysticerci in brain rather than the side effect of the drug itself. This fact should be borne in mind when treating cerebral cysticercosis with praziquantel which is highly recommended.